(S)-2-haloacid dehalogenase


In enzymology, a -2-haloacid dehalogenase is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are -2-haloacid and HO, whereas its two products are -2-hydroxyacid and halide.
This enzyme belongs to the family of hydrolases, specifically those acting on halide bonds in carbon-halide compounds. The systematic name of this enzyme class is -2-haloacid halidohydrolase. Other names in common use include 2-haloacid dehalogenase, 2-haloacid halidohydrolase , 2-haloalkanoic acid dehalogenase, 2-haloalkanoid acid halidohydrolase, 2-halocarboxylic acid dehalogenase II, DL-2-haloacid dehalogenase, L-2-haloacid dehalogenase, and L-DEX. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,2-dichloroethane degradation.

Structural studies

As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes,,,,,,,,, and.