1469

January–December

• February 4 - Battle of Qarabagh: Uzun Hasan decisively defeats the Timurids of Abu Sa'id Mirza.
• August - October: Caister Castle in England is besieged by John de Mowbray, 4th Duke of Norfolk.
• October 19 - Ferdinand II of Aragon marries Isabella I of Castile in Valladolid, bringing about a dynastic union.

  Date unknown

• Sigismund of Austria sells Upper-Elsass to Charles the Bold, in exchange for aid in a war against the Swiss.
• Moctezuma I, Aztec ruler of Tenochtitlan, dies and is succeeded by Axayacatl.
• Anglo-Hanseatic War breaks out.
• Marsilio Ficino completes his translation of the collected works of Plato, writes Commentary on Plato's Symposium on Love, and starts to work on Platonic Theology.

  Births

• February 13 - Elia Levita, Renaissance Hebrew grammarian
• February 20 - Thomas Cajetan, Italian philosopher
• March 20 - Cecily of York, English princess
• April 15 - Guru Nanak, Indian Sikh guru
• April 29 - William II, Landgrave of Hesse
• May 3 - Niccolò Machiavelli, Italian historian and political author
• May 31 - King Manuel I of Portugal
• June 20 - Gian Galeazzo Sforza, Duke of Milan
• August 4 - Margaret of Saxony, Duchess of Brunswick-Lüneburg
• August 26 - King Ferdinand II of Naples
• date unknown
• * John III of Navarre
• * Silvio Passerini, Italian politician
• * Laura Cereta, Italian humanist and feminist
• probable - Vasco da Gama, Portuguese explorer

  Deaths

• May 30 - Lope de Barrientos, powerful Castilian bishop and statesman
• August 12 - Richard Woodville, 1st Earl Rivers
• September 25 - Margaret of Brittany, Breton duchess consort
• October 8 - Filippo Lippi, Italian artist
• December 2 - Piero di Cosimo de' Medici, ruler of Florence
• December 31 - King Yejong of Joseon
• date unknown
• * Abu Sa'id Mirza, ruler of Persia and Afghanistan
• * Niccolò Da Conti, Italian merchant and explorer
• * Andrew Gray, 1st Lord Gray
• * Moctezuma I, Aztec ruler of Tenochtitlan, son of Huitzilihuitl