15-hydroxyprostaglandin dehydrogenase (NAD+)


Hydroxyprostaglandin dehydrogenase 15-, also called 15-hydroxyprostaglandin dehydrogenase,, is an enzyme that catalyzes the following chemical reaction:
Thus, the two substrates of this enzyme are --11alpha,15-dihydroxy-9-oxoprost-13-enoate and NAD+, whereas its 3 products are -11alpha-hydroxy-9,15-dioxoprost-13-enoate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is --11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase. Other names in common use include NAD+-dependent 15-hydroxyprostaglandin dehydrogenase , PGDH, 11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase, 15-OH-PGDH, 15-hydroxyprostaglandin dehydrogenase, 15-hydroxyprostanoic dehydrogenase, NAD+-specific 15-hydroxyprostaglandin dehydrogenase, prostaglandin dehydrogenase, and 15-hydroxyprostaglandin dehydrogenase .

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code.