Nebraska hosted nearby Hastings College to open the season. The Bugeaters dominated the undermatched Broncos, setting new program records for points scored and margin of victory in a 76–0 shutout win.
Iowa State
Nebraska jumped out to a halftime lead and held on in the second half to extend its winning streak to seven games.
Tarkio
Nebraska jumped out to a quick 12–0 lead and shut down Tarkio's offense to win 24–0.
Nebraska overpowered William Jewell in Kansas Cityen route to a 38–0 shutout victory, NU's seventh shutout in its previous nine games. This was the only game ever played between Nebraska and William Jewell.
at Missouri
Just two days after defeating William Jewell, Nebraska faced Missouri in Columbia. The Tigers jumped out to a 6–0 lead, but Nebraska answered with 47 unanswered points to earn a dominant win over Missouri for the second consecutive season.
Grinnell
Grinnell forced the game's cancellation, claiming Nebraska did not follow requirements in selecting game officials.
at Kansas
Kansas lost a key player to injury early in the game, and was unable to keep up with Nebraska. This was Nebraska's 11th consecutive victory.
at KC Medics
Nebraska faced Kansas City Medical School just two days after defeating Kansas. KC ended NU's winning streak with a resounding 24–0 victory.
Drake
Several key Nebraska players reportedly sat out with injuries following a dense stretch of games in the weeks prior. Drake took advantage of the undermanned Bugeaters, winning 6–5 in the first-ever meeting of these teams.
Colorado
Nebraska made its first trip to Boulder in 1898, the first game in what would later become an annual rivalry. The Silver and Gold, as Colorado was known at the time, could not keep pace with the Bugeaters in the second half.
at Denver AC
A newspaper account of the time stated this game was "the most even and hardy contested fight that has been waged on the Denver gridiron". Nebraska again played with only one day off since its previous game. The Bugeaters took advantage of Denver kicking woes, staving off a late Denver drive into NU territory to win by a single point. This was the final meeting between Denver AC and Nebraska.
at Iowa
Nebraska jumped out front with an early touchdown, and led 5–0 at halftime. A late Iowa touchdown and successful point after gave the Hawkeyes a 6–5 lead, at which point the game was called on account of darkness; frequent disputes had lengthened the game and prevented its completion.