April 15 – On Opening Day, Red Ames of the New York Giants allowed no hits through nine innings. In the 10th inning he gave up a single with one out. The Giants eventually fell to the Brooklyn Superbas, 3–0, in 13 innings. In total, Ames allowed a total of seven hits.
July 2 – The Chicago White Sox collected 12 stolen bases in the course of a 15–3 victory over the St. Louis Browns. Three are steals of home, including one by pitcher Ed Walsh in the sixth inning.
August 31 – A.J. Reach Company is granted a patent for its cork-centered baseball, which will replace the hard rubber-cored one. This change will be particularly apparent in the National League in 1910 and 1911.
September 27 - The New York Giants defeat the Pittsburgh Pirates, 8–7, to snap the Pirates' sixteen game winning streak.
October 16 – The Pittsburgh Pirates defeat the Detroit Tigers, 8–0, in Game 7 of the World Series, winning their first modern World Championship, four games to three. Rookie pitcher Babe Adams earned his third victory of the series, while completing each of the games. The Tigers thus became the first American League team to win three consecutive pennants, and the first team to lose three straight World Series.
November 26 – The Philadelphia Phillies are sold for $350,000 to a group headed by sportswriter Horace Fogel. Because of his dual roles, Fogel will become the only executive barred from a league meeting.
January 2 – Paddy Quinn, 59, catcher/outfielder for the Kekiongas/Western/Dark Blues/White Stockings National Association teams from 1871 to 1877.
January 14 – Togie Pittinger, 37, pitcher who posted a 115–113 record and a 3.10 ERA in eight seasons with the Boston Beaneaters and Philadelphia Phillies.
February 4 – John Clarkson, 47, pitcher for Chicago, Boston and Cleveland who won over 325 games, then a National League record with six 30-win seasons, including 53 and a no-hitter ; ; leading the league for the most innings pitched four times, and in strikeouts, games and complete games three times each.
February 17 – Jim Burns, , outfielder for the Kansas City Cowboys and Washington Statesmen of the American Association.
April 3 – George Barclay, 42, left fielder for the St. Louis Cardinals and the Boston Beaneaters, who also was credited with inventing the first-ever football helmet in 1896.
April 6 – Doggie Miller, 44, catcher for Pittsburgh from 1884 to 1893 who scored 80 runs five times, batted.339 for 1894 St. Louis Browns.
April 17 – Oscar Westerberg, 27, shortstop for the 1907 Boston Doves of the National League.
April 26 – Mike Dorgan, 55, Outfielder for 10 seasons, and player-manager for three, from 1877–1890.
April 29 – Doc Powers, 38, who was catching in the first game played in Shibe Park in Philadelphia when he crashed into a wall going after a pop fly. He remained in the game, but suffered from internal injuries that took his life two weeks later, when gangrene set in after three operations. He was the first major leaguer to die from injuries sustained during a game.
June 20 – Rudy Kemmler, 49?, catcher for eight seasons from 1879 to 1889.
July–September
July 5 – Frank Selee, 49, manager who guided Boston to five National League pennants and later built foundation of championship Cubs teams, collecting a.607 winning percentage –highest among managers of 1500 games–, and 1284 victories to rank second all-time upon retirement.
September 5 – Bill Popp, 32, pitcher who posted a 2–6 record in nine games for the 1902 St. Louis Cardinals.
September 17 – Herman Long, 43, shortstop for the Boston Beaneaters who batted.300 four times, led NL in runs in 1893 and home runs in 1900; set career marks for putouts and total chances, led league in double plays three times and in putouts and fielding average twice each.
September 20 – Joe Wright, 40, center fielder for the Louisville Colonels and Pittsburgh Pirates.
October–December
October 13 – Sleeper Sullivan, 50, Irish catcher who played for the Brown Stockings/Bisons/Browns/Maroons/Eclipse teams from 1881 to 1884.
October 26 – Frank Siffell, German catcher for the Philadelphia Athletics of the American Association.
October 29 – John Lyston, 42, pitcher for the Columbus Solons and Cleveland Spiders.
November 5 – Walt Kinzie, 51, shortstop for the Wolverines, White Stockings and Browns from 1882 to 1884.
December 22 – Jimmy Sebring, 27, outfielder for the Pittsburgh, Cincinnati, Brooklyn and Washington teams from 1902 to 1909, who became the first player in World Series history to hit a home run.
December 23 – Harry H. Gilbert, 41, second baseman for the 1890 Pittsburgh Alleghenys of the National League..
