To open the 1912 season, Alabama shutout the Marion Military Institute 52–0 at The Quad in Tuscaloosa. The Crimson Tide took a 20–0 lead behind a trio of first quarter touchdowns on a pair of runs by Holt Andrews McDowell and another by Adrian Van de Graaff. They then extended their lead to 33–0 at halftime behind touchdown runs by Hargrove Van de Graaff and Charlie Joplin. After a scoreless third, Alabama scored on a trio of fourth quarter touchdowns and made the final score 52–0. The final points were scored on runs by McDowell, Hargrove Van de Graaff and W. A. Barnes. The victory improved Alabama's all-time record against Marion to 4–0.
In their second game of the season, Alabama shutout Birmingham College 62–0 at The Quad. Although Adrian Van de Graaff, Charles Long and Farley Moody, the Crimson Tide thoroughly outmatched Birmingham. Touchdowns were scored by Hargrove Van de Graaff, Everett Wilkinson, Holt Andrews McDowell, Charlie Joplin and Morgan Stickney. The victory brought Alabama's all-time record against Birmingham College to 3–0. The starting lineup was Hargrove Van de Graaff, James Gibbons, C. M. Hamilton, C. D. Riddle, Julius W. Hicks, T. D. Boman, Raymond Jones, Charlie Joplin, J. H. G. Riley, Holt Andrews McDowell, Everett Wilkinson.
Georgia Tech
One source claims Tech athlete Al Loeb "is best remembered for the 1912 Tech-Alabama game." The Tide were favored and outweighed the Tech team. Loeb gave a rousing pep talk before the game. Coach John Heisman said "I think Loeb's speech did it. I've never seen madder playing than Al Loeb did that day and inspired by him, we won." Loeb broke three fingers during the game, but had the doctor tape them up and returned to the fray to lead Tech to a 20-3 victory. Loeb recalled "They were supposed to write their own score. We licked 'em 20-3. 'Tis said I didn't miss a tackle all day. And there were plenty of 'em made... Also, coach John Heisman had a heavy shift that left me on the end so I was eligible as a pass receiver. I caught a couple, too...I was also called upon to do a bit of blocking. We ran series plays, three or four consecutively. We had no huddle -- just lined up, and without a signal we were gone. It seemed just a bit speedier than at present." The starting lineup was: H. Vandergraaf, Grady, Hamilton, Riddle, Hicks, Barnes, Wilkinson, A. Vandergraaf, McDowell, Stickney.
Mississippi A&M
Alabama had its second consecutive SIAA loss over Mississippi A&M.
Georgia
In the Georgia game, the Bulldogs ran a trick play in which they threw the ball to a receiver who was dressed as a waterboy, on the field, carrying a bucket. The play did not prove decisive, as Georgia fumbled the ball away soon after, but the Bulldogs won the game after they recovered a botched Alabama field goal and scored in the final minutes. Coach Graves accused Coach Cunningham of violating the ethics of the game.
The Tide finished the season with a surprising tie against Sewanee in what was the first Alabama football game played at Rickwood Field. "There was a saying in the South that all Sewanee had to do to defeat Alabama was to show the Alabamians a purple jersey."
