Although this was the first French Grand Prix since the end of the first World War, the initial entry featured entries from four countries. The US was represented by eventual winner Duesenberg, and France by Ballot and Mathis, the latter of which was based in Strasbourg, which was part of Germany before World War I. The three Italian Fiats entered did not materialise due to labour issues. The newly formed British-French Sunbeam-Talbot-Darracq originally entered 7 nearly identical cars as 3 makes, Sunbeam, Talbot and Talbot-Darracq, however due to a lack of preparation, the two Sunbeams were withdrawn, while André Dubonnet - originally entered in a Talbot-Darracq - replaced the injured Inghilbert in the fourth Duesenberg and was not himself replaced by Talbot-Darracq for the race. As the first major Grand Prix since the War, it was decided that engine regulations should match those of the Indianapolis 500 with a 3-litre maximum. The race started at 9 am under threatening clouds, with the first pair away being Émile Mathis and Ralph DePalma, with DePalma making a considerably better start. The other cars followed in pairs at one-minute intervals, with Andre Dubonnet last to start on his own in a Duesenberg. Fastest on the first lap were both DePalma and Joe Boyer in a Duesenberg, equal with 8 minutes 16, with the third-place also a tie, between Murphy in a Duesenberg and Jean Chassagne in a Ballot. By the end of the second lap, the order was more established, with Murphy leading Boyer, Chassagne, and DePalma. The battle was close between the Duesenbergs, with their superior brakes, and the Ballots, with their superior cornering, whilst the S.T.D.s struggled with tire and road-holding problems, with Andre Boillot the only S.T.D. to drive consistently, holding sixth place in the early laps. The order changed little near the front, with Murphy pulling nearly a two-minute lead by lap 7. Chassagne overtook Boyer for second on the ninth lap. Murphy made a pitstop at the end of lap 10 but didn't lose the lead, however, Chassagne was now close behind and was able to take the lead during lap 11. By half distance, Chassagne leads Boyer who had also overtaken Murphy, now third. Guyot was not far behind in fourth, then a much larger gap to the lower positions, lead by DePalma. On lap 17, Chassagne made a pitstop to refuel but his fuel tank had burst and was beyond repair. On the very next lap, Boyer who had just inherited the lead suffered a mechanical failure, giving the lead back to Murphy ahead of a slowing Guyot. Murphy would hold onto this lead until the end, but behind him, the fight for second place was more dramatic. Guyot had a large gap back to third place, but when he stopped for fuel and water on lap 28, he was unable to restart. His mechanic became very tired trying to push-start the car and was replaced by Arthur Duray who was at the race as a spectator. They were able to restart but this had damaged the clutch forcing another stop and they ended up in sixth place. DePalma then took second, but he too had considerable difficulty restarting but was still able to finish ahead of third-placed Jules Goux in a 2-litre Ballot who finished the race without stopping.
