Sources: The season opened with a 31-6 defeat over the Oglethorpe Stormy Petrels. Red Barron scored two touchdowns, and Oglethorpe's Adrian Maurer had a 90-yard touchdown run. The starting lineup was J. Staton, Johnson, McIntyre, Frye, Davis, Lyman, A. Staton, McDonough, Barron, Brewster, Hunt.
Davidson
In the second week of play, Tech beat the Davidson Wildcats 19-0. Red Barron ran for 116 yards and two touchdowns despite playing for only part of the contest. The starting lineup was J. Staton, Johnson, McIntyre, Frye, Davis, A. Staton, Mitchel, McDonough, Barron, Rather, Hunt.
Alabama
Sources: Tech defeated the Alabama Crimson Tide 33-7. Alabama's score came when Country Oliver returned a kickoff 95 yards. The starting lineup was J. Staton, Cornell, McIntyre, Frye, Davis, A. Staton, Mitchell, McDonough, Barron, McWhorter, Hunt.
Navy
Red Barron played well in the 13-0 loss to the Navy Midshipmen. The starting lineup was J. Staton, Connell, McIntyre, Frye, Davis, A. Staton, Mitchell, McDonough, Barron, McWhorter, Hunt.
Tech played Knute Rockne's Notre Dame Fighting Irishfor the first time. The Four Horsemen were sophomores playing their first year on the varsity, and beat Tech 13-3. The Irish stopped Red Barron. The starting lineup was J. Staton, Usry, McConnel, Frye, Davis, Lyman, A. Staton, McDonough, Barron, Brewster, Hunt
Clemson
The Clemson Tigers were defeated 21–7. Coach Alexander used a different platoon each quarter. The starting lineup was J. Staton, Usery, McConell, Frye, Davis, Lyman, A. Staton, McDonough, Barron, Brewster, Hunt.
Georgetown
Sources: Tech's backfield starred in a 19-7 defeat of the Georgetown Blue and Gray. Jack McDonough scored two touchdowns and Brewster another. Flavin scored for Georgetown. The starting lineup was J. Staton, Usry, McIntyre, Frye, Davis, A. Staton, Mitchell, McDonough, Barron, Brewster, Hunt.
Sources: The Tornado shutout the NC State Wolfpack 17–0. Henry Reeves made a 40-yard drop kick. The starting lineup was Gardner, Johnson, McConnell, Fleetwood, Borum, Lyman, Mitchell, McDonough, Barron, Brewster, Hunt
Auburn
Sources: Tech beat coach Mike Donahue's rival Auburn Tigers to secure a share of the SoCon championship. The 1922 team is considered one of Auburn's greatest football teams, and they had lost only to undefeated Army. Still Tech held the Tigers without a first down in the second and third periods. Ed Sherling scored Auburn's touchdown on a 16-yard rush. The starting lineup was J. Staton, Usry, McIntyre, Frye, Davis, Lyman, A. Staton, McDonough, Barron, Brewster, Hunt.
The following chart provides a visual depiction of Tech's lineup during the 1922 season with games started at the position reflected in parenthesis. The chart mimics the offense after the jump shift has taken place.