1942–43 Segunda División
Overview before the season
24 teams joined the league, including two relegated from the 1941–42 La Liga and 3 promoted from Divisiones Regionales.;Relegated from La Liga:
- Hércules
- Real Sociedad
- Cultural Leonesa
- Tarrasa
- Alcoyano
Group 1
Teams
| Club | City | Stadium |
| Arenas Club | Guecho | Ibaiondo |
| Club Baracaldo | Baracaldo | Lasesarre |
| Cultural y Deportiva Leonesa | León | La Corredera |
| Club Ferrol | Ferrol | Inferniño |
| Real Gijón | Gijón | El Molinón |
| UD Salamanca | Salamanca | El Calvario |
| Real Santander SD | Santander | El Sardinero |
| Real Valladolid Deportivo | Valladolid | José Zorrilla |
League table
Results
Top goalscorers
Top goalkeepers
Group 2
Teams
| Club | City | Stadium |
| Deportivo Alavés | Vitoria | Mendizorroza |
| CD Constancia | Inca | Camp d’Es Cos |
| AD Ferroviaria | Madrid | Campo de Delicias |
| Gerona CF | Gerona | Vista Alegre |
| CA Osasuna | Pamplona | San Juan |
| Real Sociedad | San Sebastián | Atocha |
| CD Sabadell FC | Sabadell | Cruz Alta |
| CD Tarrasa | Tarrasa | Pi i Maragall |
League table
Results
Top goalscorers
Top goalkeepers
Group 3
Teams
| Club | City | Stadium |
| CD Alcoyano | Alcoy | El Collao |
| Cádiz CF | Cádiz | La Mirandilla |
| SD Ceuta | Ceuta | Campo de Deportes |
| Elche CF | Elche | Altabix |
| Hércules CF | Alicante | La Viña |
| CD Málaga | Málaga | La Rosaleda |
| Real Murcia | Murcia | Estadio de La Condomina |
| Xerez Club | Jerez de la Frontera | Domecq |