| Week | Date | Opponent | Result | Attendance | Summary |
| 1 | September 12, 1976 | at Atlanta Falcons | W 30–14 | 53,607 | With James Harris injured, Ron Jaworski opened the Rams' season as the starter. Jaworski ran for a touchdown and passed for another, but was injured late. RB's Lawrence McCutcheon and John Cappelletti each ran for over 100 yards and the Ram defense picked off three passes, including an interception return touchdown by CB Monte Jackson. |
| 2 | September 19, 1976 | at Minnesota Vikings | T 10–10 | 47,310 | With Harris and Jaworski both down, the Rams turned to rookie Pat Haden. Haden played it close to the vest with ball-control as McCutcheon and Cappelletti both went over 100 yards rushing for the second straight week. Rams overcame a 10–0 deficit in the fourth to forge the tie. |
| 3 | September 26, 1976 | New York Giants | W 24–10 | 60,698 | Harris returned as the starter and passed for a touchdown as the Rams scored 24 unanswered points after a 10–0 first quarter Giants lead. Rams' defense picked off 4 passes. |
| 4 | October 3, 1976 | at Miami Dolphins | W 31–28 | 60,753 | In perhaps his finest performance as Ram QB, Harris passed for 436 yards and two touchdowns and ran for another as he helped the Rams overcome a 14–0 halftime deficit. Tom Dempsey won it with a late field goal. |
| 5 | October 11, 1976 | San Francisco 49ers | L 16–0 | 80,532 | In a Monday-night showdown against the upstart 49ers, Rams were dominated at home by the Niner defense, especially the pass rush. The 49ers sacked Harris 10 times, six alone by DE Tommy Hart. Harris injured his shoulder late and would miss the next few games. |
| 6 | October 17, 1976 | Chicago Bears | W 20–12 | 71,751 | Rams went with a Haden/Jaworski platoon. McCutcheon scored two touchdowns on a run and on a pass from Haden. |
| 7 | October 24, 1976 | at New Orleans Saints | W 16–10 | 51,984 | Despite being outgained in yards 422–214 and completing only five passes, the Rams won on a Haden-to-Harold Jackson touchdown bomb late. Rams defense did record nine QB sacks. Jaworski would be injured, but Harris would return for the next game. |
| 8 | October 31, 1976 | Seattle Seahawks | W 45–6 | 52,035 | Harris got the start in this blowout and passed for two touchdowns. Monte Jackson had his second interception return touchdown of the season as well. |
| 9 | November 7, 1976 | at Cincinnati Bengals | L 20–12 | 52,480 | Ken Anderson passed for two touchdowns. Harris played the entire game, but coach Chuck Knox announced that Haden would be his starter for the remainder of the season. |
| 10 | November 14, 1976 | St. Louis Cardinals | L 30–28 | 64,698 | Haden started and passed for a touchdown and ran for one, but the Rams couldn't hold off a Cardinal comeback led by Jim Hart's 324 passing yards. Jim Bakken won it with a late FG. |
| 11 | November 21, 1976 | at San Francisco 49ers | W 23–3 | 58,573 | Rams avenged the earlier loss by holding the 49ers to 88 net yards of offense and nine of 28 pass completions. Haden only completed 3 passes, but one was for a touchdown to Ron Jessie. Jackson had his third INT return touchdown. |
| 12 | November 28, 1976 | New Orleans Saints | W 33–14 | 54,906 | Haden threw for two scores and ran for another and McCutcheon had 119 yards rushing and a touchdown as the Rams rolled to a 26–7 halftime lead and cruised. Rams had 323 yards on the ground. |
| 13 | December 4, 1976 | Atlanta Falcons | W 59–0 | 57,366 | McCutcheon scored 3 touchdowns and Haden ran for one. Harris entered the game in the 4th and had a touchdown run and touchdown pass as the Rams mauled the Falcons. |
| 14 | December 11, 1976 | at Detroit Lions | W 20–17 | 73,470 | Haden started, but left the game early with strained knee ligaments. Harris came in and led the Rams to a comeback win, but Haden would be the starter for the playoffs. |
