1980–81 FIBA European Cup Winners' Cup
The 1980–81 FIBA European Cup Winners' Cup was the fifteenth edition of FIBA's 2nd-tier level European-wide professional club basketball competition, contested between national domestic cup champions, running from 7 October 1980, to 18 March 1981. It was contested by 20 teams, two less than in the previous edition.
Squibb Cantù defeated FC Barcelona, in the final held in Rome, winning the FIBA European Cup Winner's Cup for a fourth time.Participants
Second round
Quarterfinals
Group A
| Team | Pld | Pts | W | L | PF | PA | PD |
| 1. |  FC Barcelona | 6 | 11 | 5 | 1 | 570 | 468 | +102 |
| 2. |  Turisanda Varese | 6 | 10 | 4 | 2 | 518 | 466 | +52 |
| 3. |  Parker Leiden | 6 | 9 | 3 | 3 | 506 | 536 | -30 |
| 4. |  Efes Pilsen | 6 | 6 | 0 | 6 | 433 | 557 | -124 |
Group B
| Team | Pld | Pts | W | L | PF | PA | PD |
| 1. | Squibb Cantù | 6 | 12 | 6 | 0 | 556 | 471 | +85 |
| 2. |  Cibona | 6 | 10 | 4 | 2 | 536 | 515 | +21 |
| 3. |  Moderne | 6 | 7 | 1 | 5 | 521 | 530 | -9 |
| 4. |  Žalgiris | 6 | 7 | 1 | 5 | 466 | 563 | -97 |
Semifinals
Final
March 18, Palaeur, Rome
