2000 Major League Baseball draft
First Round Selections
| Pick | Player | Team | Position | Hometown/School |
| 1 | Adrián González | Florida Marlins | 1B | Eastlake High School |
| 2 | Adam Johnson | Minnesota Twins | RHP | Cal-State Fullerton |
| 3 | Luis Montanez | Chicago Cubs | SS | Miami, FL |
| 4 | Mike Stodolka | Kansas City Royals | LHP | Corona, California |
| 5 | Justin Wayne | Montreal Expos | RHP | Stanford |
| 6 | Rocco Baldelli | Tampa Bay Devil Rays | OF | Warwick, Rhode Island |
| 7 | Matt Harrington | Colorado Rockies | RHP | Palmdale, California |
| 8 | Matt Wheatland | Detroit Tigers | RHP | San Diego, CA |
| 9 | Mark Phillips | San Diego Padres | LHP | Hanover, Pennsylvania |
| 10 | Joe Torres | Anaheim Angels | LHP | Kissimmee, Florida |
| 11 | Dave Krynzel | Milwaukee Brewers | OF | Henderson, Nevada |
| 12 | Joe Borchard | Chicago White Sox | OF | Stanford |
| 13 | Shaun Boyd | St. Louis Cardinals | 2B | Oceanside, California |
| 14 | Beau Hale | Baltimore Orioles | RHP | Texas |
| 15 | Chase Utley | Philadelphia Phillies | 2B | UCLA |
| 16 | Billy Traber | New York Mets | LHP | Loyola Marymount |
| 17 | Ben Diggins | Los Angeles Dodgers | RHP | University of Arizona |
| 18 | Miguel Negron | Toronto Blue Jays | OF | Caguas, PR |
| 19 | Sean Burnett | Pittsburgh Pirates | LHP | Wellington, Florida |
| 20 | Chris Bootcheck | Anaheim Angels | RHP | Auburn |
| 21 | John Bonser | San Francisco Giants | RHP | Pinellas Park, Florida |
| 22 | Phil Dumatrait | Boston Red Sox | LHP | Bakersfield College |
| 23 | David Espinosa | Cincinnati Reds | SS | Miami, FL |
| 24 | Blake Williams | St. Louis Cardinals | RHP | S.W. Texas State |
| 25 | Scott Heard | Texas Rangers | C | San Diego, CA |
| 26 | Corey Smith | Cleveland Indians | SS | Piscataway, New Jersey |
| 27 | Robert Stiehl | Houston Astros | RHP | El Camino College |
| 28 | David Parrish | New York Yankees | C | Michigan |
| 29 | Adam Wainwright | Atlanta Braves | RHP | Brunswick, Georgia |
| 30 | Scott Thorman | Atlanta Braves | 3B | Cambridge, ON |
Compensation picks
| Pick | Player | Team | Position | School |
| 31 | Aaron Heilman | Minnesota Twins | RHP | University of Notre Dame |
| 32 | Tripper Johnson | Baltimore Orioles | RHP | Newport High School |
| 33 | Dustin McGowan | Toronto Blue Jays | RHP | Long County High School |
| 34 | Dustin Moseley | Cincinnati Reds | RHP | Arkansas High School |
| 35 | Carlton Godwin | Texas Rangers | OF | University of North Carolina |
| 36 | Bobby Keppel | New York Mets | RHP | De Smet Jesuit High School |
| 37 | Derek Thompson | Cleveland Indians | LHP | Land O'Lakes High School |
| 38 | Kelly Johnson | Atlanta Braves | SS | Westwood High School |
| 39 | Chad Hawkins | Texas Rangers | RHP | Baylor University |
| 40 | Aaron Herr | Atlanta Braves | SS | Hempfield High School |
Compensation Picks
Background
The Florida Marlins made Adrián González of Eastlake High School in Chula Vista, California the first overall selection in the 2000 First-Year Player Draft. González, who was rated as the best pure high school hitter in the draft by Baseball America, was the first high school first baseman taken first overall since the New York Yankees chose Ron Blomberg in 1967. In his senior year, González hit.645 with 13 home runs and 34 RBI.Among the college players chosen was David Parrish, son of former major leaguer Lance Parrish, by the New York Yankees with the 28th pick. In addition, David Espinosa, a high school shortstop from Miami, Florida, became the first RBI alumnus ever selected in the first round of the draft.
Infielder Xavier Nady, second round pick of the San Diego Padres out of the University of California, went straight to the Major Leagues in 2000. He became the 19th player to do so since the draft started in 1965.
Other notable players
- Xavier Nady, 2nd round, 49th overall by the San Diego Padres
- Chris Narveson, 2nd round, 53rd overall by the St. Louis Cardinals
- Brian Tallet, 2nd round, 55th overall by the Cleveland Indians
- Joel Hanrahan, 2nd round, 57th overall by the Los Angeles Dodgers
- Manny Delcarmen, 2nd round, 62nd overall by the Boston Red Sox
- Chad Qualls, 2nd round, 67th overall by the Houston Astros
- Grady Sizemore, 3rd round, 75th overall by the Montreal Expos
- Michael Morse, 3rd round, 82nd overall by the Chicago White Sox
- Chris Young, 3rd round, 89th overall by the Pittsburgh Pirates
- Todd Wellemeyer, 4th round, 103rd overall by the Chicago Cubs
- David DeJesus, 4th round, 104th overall by the Kansas City Royals
- Cliff Lee, 4th round, 105th overall by the Montreal Expos
- Yadier Molina, 4th round, 113th overall by the St. Louis Cardinals
- Laynce Nix, 4th round, 124th overall by the Texas Rangers
- Garrett Atkins, 5th round, 137th overall by the Colorado Rockies
- Bobby Jenks, 5th round, 140th overall by the Anaheim Angels
- Taylor Buchholz, 6th round, 175th overall by the Philadelphia Phillies
- Aaron Hill, 7th round, 200th overall by the Anaheim Angels
- Dontrelle Willis, 8th round, 223rd overall by the Chicago Cubs
- Nick Masset, 8th round, 244th overall by the Texas Rangers
- Brandon Webb, 8th round, 249th overall by the Arizona Diamondbacks
- Edwin Encarnación, 9th round, 274th overall by the Texas Rangers
- Clint Barmes, 10th round, 287th overall by the Colorado Rockies
- Brad Hawpe, 11th round, 317th overall by the Colorado Rockies
- Corey Hart, 11th round, 321st overall by the Milwaukee Brewers
- Freddy Sanchez, 11th round, 332nd overall by the Boston Red Sox
- Jason Kubel, 12th round, 342nd overall by the Minnesota Twins
- Brian Bruney, 12th round, 369th overall by the Arizona Diamondbacks
- Ryan Church, 14th round, 426h overall by the Cleveland Indians
- James Shields, 16th round, 466th overall by the Tampa Bay Devil Rays
- Josh Willingham, 17th round, 491st overall by the Florida Marlins
- Paul Maholm, 17th round, 492nd overall by the Minnesota Twins, but did not sign
- Mike Napoli, 17th round, 500th overall by the Anaheim Angels
- Rich Harden, 17th round, 510th overall by the Oakland Athletics
- Michael Bourn, 19th round, 577th overall by the Houston Astros, but did sign
- José Bautista, 20th round, 599th overall by the Pittsburgh Pirates
- Jason Bay, 22nd round, 645th overall by the Montreal Expos
- Jason Hammel, 23rd round, 686th overall by the Seattle Mariners, but did not sign
- Nate McLouth, 25th round, 749th overall by the Pittsburgh Pirates
- Chad Cordero, 26th round, 769th overall by the San Diego Padres, but did not sign
- Ian Snell, 26th round, 779th overall by the Pittsburgh Pirates
- Ian Kinsler, 29th round, 879th overall by the Arizona Diamondbacks, but did not sign
- Adam LaRoche, 29th round, 880th overall by the Atlanta Braves
- Brian Wilson, 30th round, 906th overall by the Cleveland Indians, but did not sign
- Nick Blackburn, 34th round, 1006th overall by the Tampa Bay Devil Rays, but did not sign
- Russell Martin, 35th round, 1035th overall by the Montreal Expos, but did not sign
- Tim Stauffer, 36th round, 1074th overall by the Baltimore Orioles, but did not sign
- Scott Baker, 36th round, 1079th overall by the Pittsburgh Pirates, but did not sign
- Tom Gorzelanny, 38th round, 1132nd overall by the Chicago White Sox, but did not sign
- Luke Scott, 45th round, 1327th overall by the Tampa Bay Devil Rays, but did not sign
- David Murphy, 50th round, 1439th overall by the Anaheim Angels, but did not sign
NFL players drafted
- Mewelde Moore, 4th round, 109th overall by the San Diego Padres
- Michael Vick, 30th round, 887th overall by the Colorado Rockies, but did not sign
- Ronnie Brown, 42nd round, 1253rd overall by the Seattle Mariners, but did not sign
- Freddie Mitchell, 50th round, 1441st overall by the Chicago White Sox, but did not sign
- Brooks Bollinger, 50th round, 1443rd overall by the Los Angeles Dodgers, but did not sign