2006 FIFA World Cup qualification – CAF First Round
In the First Round, 42 teams were paired 2-by-2 and played knockout matches home-and-away. The 21 winners would advance to the Second Round where they would meet the other 9 teams that qualify directly to the Second Round. Those teams are the 5 teams that qualified for the 2002 World Cup Finals and the 4 highest-ranking teams in FIFA world rankings of 25 June 2003.Matches
- Mali won 4–1 on aggregate and advanced to the Second Round.
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- Benin won 4–3 on aggregate and advanced to the Second Round.
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- Zambia won 5–1 on aggregate and advanced to the Second Round.
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- Botswana won 4–1 on aggregate and advanced to the Second Round.
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- Togo won 2–1 on aggregate and advanced to the Second Round.
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- Libya won 9–0 on aggregate and advanced to the Second Round.
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- Kenya won 3–0 on aggregate and advanced to the Second Round.
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- Algeria won 7–0 on aggregate and advanced to the Second Round.
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- Uganda won 4–3 on aggregate and advanced to the Second Round.
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- Sudan won 3–0 on aggregate and advanced to the Second Round.
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- Zimbabwe won 4–2 on aggregate and advanced to the Second Round.
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- Cape Verde won 4–1 on aggregate and advanced to the Second Round.
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- Gabon won 4–1 on aggregate and advanced to the Second Round.
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- Congo won 2–1 on aggregate and advanced to the Second Round.
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- Malawi won 3–1 on aggregate and advanced to the Second Round.
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- Rwanda won 4–1 on aggregate and advanced to the Second Round.
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- Guinea won 5–3 on aggregate and advanced to the Second Round.
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- Liberia won 3–2 on aggregate and advanced to the Second Round.
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- Ghana won 7–0 on aggregate and advanced to the Second Round.
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