The clubs placed 2nd to 5th in each division would participate in a promotion play-offs, a knockout tournament. In the first round, in each division the 2nd placed club would play the 5th placed club and the 3rd placed club would play the 4th placed club. In the second round, the two first round winners would play each other. In the first two rounds the higher ranked club would have home advantage. In the third round both divisional play-off winner would play each other in a neutral venue for a place in a promotion/relegation play-off against the 14th placed club in Liga Leumit, which would be played over two home and away matches.
Second and third placed clubs played single match at home against the fourth and fifth placed clubs in their respective regional division. ---- Hapoel Asi Gilboa and Hapoel Afula and Maccabi Kiryat Malakhi and Maccabi Kabilio Jaffa advanced to the second round. ----
Second round
The winners of the first round played single match at home of the higher ranked club. ---- Hapoel Asi Gilboa and Maccabi Kabilio Jaffa advanced to the third round. ----
Third round
Hapoel Asi Gilboa and Maccabi Kabilio Jaffa faced each other for a single match in neutral venue. the winner advanced to the fourth round against the 14th placed club in Liga Leumit. Maccabi Kabilio Jaffa advanced to the fourth round. ----
Fourth round
Maccabi Kabilio Jaffa faced the 14th placed in 2010–11 Liga LeumitHakoah Ramat Gan. the winner on aggregate earned a spot in the 2011–12 Liga Leumit. The matches took place on May 26 and 31, 2011. ---- Hakoah Ramat Gan won 3–2 on aggregate and remained in Liga Leumit. Maccabi Kabilio Jaffa remained in Liga Alef.
Relegation play-offs
North play-off
The 14th placed club in Liga Alef North, Ironi Sayid Umm al-Fahm, faced the Liga Bet play-offs winner, F.C. Givat Olga. the winner earned a spot in the 2011–12 Liga Alef. Ironi Sayid Umm al-Fahm relegated to Liga Bet.
South play-off
The 14th placed club in Liga Alef South, Hapoel Nahlat Yehuda, faced the Liga Bet play-offs winner, Ortodoxim Lod. the winner earned a spot in the 2011–12 Liga Alef. Hapoel Nahlat Yehuda relegated to Liga Bet.
