This season's format for the main event has changed again. The announcement of the format was given during the draw of the round 32 in the headquarters of the FFU. All matches consist of a single game and would include extra time and series of penalties if necessary to identify a winner. The broadcast of the draw was officially conducted for the first time by one of the sponsors of the Ukrainian Premier League. The draw was blind. All participants were ranked according to their table standings on September 8, 2010 and listed in that order for the draw. All seeds of pairs were numerated such as the first pair consisted of number 1 and number 2, the second pair of number 3 and number 4, the third – 5 and 6, and so on. Clubs of a lower league when seeded with one from a higher would receive a home advantage. However, in case for the same league seeded clubs, the hosting club was identified by an odd number that was drawn upon calling its name. A former Soviet player Vadym Yevtushenko was invited as a "special guest" to conduct the draw. For each announced club from the ranking list a ball with a number was drawn from a pot. According to the number, the announced club was placed into the seed with the corresponding number. The first club that was announced was FC Shakhtar Donetsk. For the Round of 16 draw was invited Viktor Leonenko as the honorary visitor. Fifty eight teams entered the Ukrainian Cup competition.
Distribution
Round and draw dates
All draws held at FFU headquarters in Kiev unless stated otherwise.
Competition schedule
First Preliminary Round
In this round entered 8 clubs from the Druha Liha, the winner of the Ukrainian Amateur Cup, and the newly admitted club from Nova Kakhovka all seeded into five fixtures. The round matches are scheduled to be played July 28, 2010. ;Notes: Match not played due to Ros Bila Tserkva's financial difficulties Qualify as Amateur Cup Champions of Ukraine 2009. The match was played on July 27, 2010
Second Preliminary Round
In this round entered all 17 clubs from Persha Liha and the higher seeded 10 clubs from the Druha Liha. They were drawn against the 5 winners of the First Preliminary Round. The round matches are scheduled were played August 18, 2010, unless otherwise noted.
Bracket
The pairings for each round were not known from the incept.
Round of 32
In this round entered all 16 teams from the Premier League. They were drawn against the 16 winners from the previous round consisting of nine clubs from the First League, six clubs from the Second League, and one representative from the amateur league. The draw took place September 8, 2010. ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ---- ;Notes:
Round of 16
In this round entered winners from the previous round. The Premier League is represented with 10 clubs, the First League – 4, and the Second League – 2. The draw for the round took place on October 1, 2010. ---- ---- ---- ---- ---- ---- ---- ;Notes: Initially the management of Feniks-Illichivets Kalinine informed their opponents that the club has removed itself from further competitions. However, four days later the club informed the PFL that their financial state had stabilized and that they would play.
Quarter-finals
In this round entered winners from the previous round. The Premier League is represented with 7 clubs and the First League with 1 club. The draw for the round took place on October 28, 2010. ---- ---- ----
Semi-finals
In this round entered winners from the previous round. The draw for the round took place on November 25, 2010. ----
Andriy Oliynyk
Luiz Adriano
Sergei Samodin