2010 Mutua Madrileña Madrid Open – Women's Singles
was the defending champion, but she lost against Klára Zakopalová in the first round.
Aravane Rezaï won in the final 6–2, 7–5 against Venus Williams.Seeds
Bye
The four Rome semifinalists received a bye into the second round. They are as follows:
Finals
Section 2
Section 3
Section 4
