2015–16 UEFA Youth League knockout phase
The 2015–16 UEFA Youth League knockout phase began on 9 February 2016 and concluded on 18 April 2016 with the final at Colovray Stadium in Nyon, Switzerland, which decided the champions of the 2015–16 UEFA Youth League. A total of 24 teams competed in the knockout phase.
Times up to 26 March 2016 were CET, thereafter times were CEST.
Round and draw dates
The schedule of the competition was as follows.| Round | Draw | Match dates |
| Play-offs | 14 December 2015, 14:00 | 9–10 February 2016 |
| Round of 16 | 15 February 2016, 13:00 | 23–24 February 2016 |
| Quarter-finals | 15 February 2016, 13:00 | 8–9 March 2016 |
| Semi-finals | 15 February 2016, 13:00 | 15 April 2016 at Colovray Stadium, Nyon |
| Final | 15 February 2016, 13:00 | 18 April 2016 at Colovray Stadium, Nyon |
Format
The knockout phase involved 24 teams: 16 teams which qualified from the UEFA Champions League Path, and eight teams which qualified from the Domestic Champions Path :- The eight group winners from the UEFA Champions League Path entered the round of 16.
- The eight group runners-up from the UEFA Champions League Path and the eight second round winners from the Domestic Champions Path entered the play-offs. The eight play-off winners advanced to the round of 16.
The mechanism of the draws for each round was as follows:
- In the draw for the play-offs, the eight second round winners from the Domestic Champions Path were drawn against the eight group runners-up from the UEFA Champions League Path, with the teams from the Domestic Champions Path hosting the match. Teams from the same association could not be drawn against each other.
- In the draw for the round of 16, the eight group winners from the UEFA Champions League Path were drawn against the eight play-off winners. Teams from the same UEFA Champions League Path group could not be drawn against each other, but teams from the same association could be drawn against each other. The draw also decided the home team for each round of 16 match.
- In the draws for the quarter-finals onwards, there were no seedings, and teams from the same UEFA Champions League Path group or the same association could be drawn against each other. The draws also decided the home team for each quarter-final, and the "home" team for administrative purposes for each semi-final and final.
Qualified teams