The eight group runners-up from the UEFA Champions League Path and the eight second round winners from the Domestic Champions Path enter the play-offs. The eight play-off winners advance to the round of 16.
Each tie in the knockout phase is played over one match. If the scores are level after full-time, the match is decided by a penalty shoot-out. The mechanism of the draws for each round is as follows:
In the draw for the play-offs, the eight second round winners from the Domestic Champions Path are drawn against the eight group runners-up from the UEFA Champions League Path, with the teams from the Domestic Champions Path hosting the match. Teams from the same association cannot be drawn against each other.
In the draw for the round of 16, the eight group winners from the UEFA Champions League Path are drawn against the eight play-off winners. Teams from the same UEFA Champions League Path group cannot be drawn against each other, but teams from the same association can be drawn against each other. The draw also decides the home team for each round of 16 match.
In the draws for the quarter-finals onwards, there are no seedings, and teams from the same UEFA Champions League Path group or the same association can be drawn against each other. The draws also decide the home team for each quarter-final, and the "home" team for administrative purposes for each semi-final and final.
On 17 July 2014, the UEFA emergency panel ruled that Ukrainian and Russian clubs would not be drawn against each other "until further notice" due to the political unrest between the countries. This restriction, if necessary, applies to the draws for the play-offs, round of 16 and quarter-finals, where matches are hosted by one of the teams, but not to the semi-finals and final, which are played at a neutral venue.
Qualified teams
UEFA Champions League Path
Domestic Champions Path
Play-offs
The draw for the play-offs was held on 12 December 2016, 14:00 CET, at the UEFA headquarters in Nyon, Switzerland. The play-offs were played on 7 and 8 February 2017.
Bracket (round of 16 onwards)
The draw for the round of 16 onwards was held on 10 February 2017, 13:00 CET, at the UEFA headquarters in Nyon, Switzerland.
Round of 16
The round of 16 matches were played on 21 and 22 February 2017.
Quarter-finals
The quarter-finals were played on 7 and 8 March 2017.
Semi-finals
The semi-finals were played on 21 April 2017 at Colovray Stadium, Nyon.
Final
The final was played on 24 April 2017 at Colovray Stadium, Nyon.
