2019 Copa Sudamericana second stage
The 2019 Copa Sudamericana second stage was played from 21 to 30 May 2019. A total of 32 teams competed in the second stage to decide the 16 places in the final stages of the 2019 Copa Sudamericana.
Draw
The draw for the second stage was held on 13 May 2019, 20:30 PYT, at the CONMEBOL Convention Centre in Luque, Paraguay. For the second stage, the teams were allocated to two pots according to their previous results in this season:
- Pot 1: 10 teams transferred from the Copa Libertadores and six best winners of the first stage from the Copa Sudamericana
- Pot 2: 16 remaining winners of the first stage from the Copa Sudamericana
The following were the 10 teams transferred from the Copa Libertadores.
| Match | Best teams eliminated in third stage | Second stage draw |
| G3 |  Atlético Nacional | Pot 1 |
| G2 |  Caracas | Pot 1 |
| Group | Third-placed teams in group stage | Second stage draw |
| A |  Palestino | Pot 1 |
| B | Deportivo Lara | Pot 1 |
| C |  Sporting Cristal | Pot 1 |
| D |  Peñarol | Pot 1 |
| E |  Atlético Mineiro | Pot 1 |
| F | Melgar | Pot 1 |
| G | Deportes Tolima | Pot 1 |
| H | Universidad Católica | Pot 1 |
The following were the 22 winners of the first stage from the Copa Sudamericana. Matches in the first stage were considered for the ranking of teams for the second stage draw.
Format
In the second stage, each tie was played on a home-and-away two-legged basis. If tied on aggregate, the away goals rule would be used. If still tied, extra time would not be played, and a penalty shoot-out would be used to determine the winner.
The 16 winners of the second stage advanced to the round of 16 of the final stages.
Matches
The first legs were played on 21–23 May, and the second legs were played on 28–30 May 2019.Match O1
----La Equidad won 4–1 on aggregate and advanced to the round of 16.
Match O2
----Independiente del Valle won 7–3 on aggregate and advanced to the round of 16.
Match O3
----Fluminense won 4–2 on aggregate and advanced to the round of 16.
Match O4
----Sporting Cristal won 6–0 on aggregate and advanced to the round of 16.
Match O5
----Argentinos Juniors won 1–0 on aggregate and advanced to the round of 16.
Match O6
----Montevideo Wanderers won 1–0 on aggregate and advanced to the round of 16.
Match O7
----Universidad Católica won 6–0 on aggregate and advanced to the round of 16.
Match O8
----Tied 1–1 on aggregate, Atlético Mineiro won on penalties and advanced to the round of 16.
Match O9
----Botafogo won 5–0 on aggregate and advanced to the round of 16.
Match O10
----Independiente won 4–3 on aggregate and advanced to the round of 16.
Match O11
----Corinthians won 4–0 on aggregate and advanced to the round of 16.
Match O12
----Colón won 3–1 on aggregate and advanced to the round of 16.
Match O13
----Zulia won 3–1 on aggregate and advanced to the round of 16.
Match O14
----Peñarol won 3–1 on aggregate and advanced to the round of 16.
Match O15
----Caracas won 2–1 on aggregate and advanced to the round of 16.
Match O16
----Tied 3–3 on aggregate, Royal Pari won on away goals and advanced to the round of 16.