3-Aminoisobutyric acid
3-Aminoisobutyric acid is a product formed by the catabolism of thymine.
During exercise, the increase of PGC-1α protein triggers the secretion of BAIBA from exercising muscles to blood. When BAIBA reaches the white fat tissue, it activates the expression of thermogenic genes via PPARα receptors, resulting in a browning of white fat cells. One of the consequences of the BAIBA activity is the increase of the background metabolism of the BAIBA target cells.
It has recently been postulated to play a role in cell metabolism, how body burns fat and regulates insulin, triglycerides, and total cholesterol.
