4-PPBP
4-PPBP is a molecule which binds to sigma receptors.
4-PPBP decreases neuronal nitric oxide synthase activity and ischemia-evoked nitric oxide production. 4-PPBP provides neuroprotection; this involves the prevention of ischemia-induced intracellular Ca2+dysregulation. 4-PPBP protects neurons using a mechanism that activates the transcription factor cyclic adenosine monophosphate response element-binding protein. Neuroprotection that is associated with 4-PPBP increases Bcl-2 expression; Bcl-2 expression is regulated by CREB.
