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A-971432
A-971432
is an
orally bioavailable
selective agonist
of
sphingosine-1-phosphate receptor 5
discovered
at
AbbVie
. It was discovered using
high-throughput chemistry
. S1P5
agonists
have been
proposed
as an
innovative
mechanism for the treatment of
neurodegenerative disorders
such as
Alzheimer's disease
and
lysosomal storage disorders
such as
Niemann–Pick disease
.
Stimulation
of
S1PR5
with A-971432 has been
shown
to preserve
blood-brain barrier
integrity
and exert a
therapeutic effect
in an
animal model
of
Huntington’s disease
.
