The road begins at a roundabout junction with the A40 road on the northern section of Oxford's ring road in Oxfordshire. It has a grade separated junction with the A34 road. From here, the road runs northwest, and has a section of dual-carriageway through the villages of Yarnton and Begbroke before reaching the town of Woodstock, home to Blenheim Palace. The road then reaches the main market street in Chipping Norton before entering the Cotswolds. The road here has many hills and turns, and is single-carriageway with some tight bends, with not much opportunity for overtaking. The road then enters Gloucestershire, and the town of Moreton in Marsh, before sweeping up through woodland until it reaches Fish Hill near Broadway in Worcestershire. At this point, it becomes 3-lane and descends steeply through some sharp bends. It then bypasses Broadway before meeting up with the A46/A435 Evesham bypass.
Evesham–Leominster
On reaching the northern end of the Evesham bypass the A44 heads northwest, passing Wyre Piddle and the town of Pershore before reaching the crossroads near Spetchley. The road then crosses the M5 motorway and onto Worcester's eastern bypass. It then turns south along the bypass before rejoining its original line west into the city itself. The road passes the Cathedral, crosses the River Severn and then meets the western end of the bypass. After leaving Worcester, the A44 continues west past the village of Broadwas, following the River Teme until Knightwick where enters Herefordshire as it climbs over Bringsty Common before descending towards Bromyard. The A44 bypasses Bromyard town centre and heads west over the downs to Bredenbury. It then crosses the River Lugg before meeting the A49Leominster bypass, where it turns left and heads through the town centre.
Leominster–Rhayader
After leaving Leominster, the A44 crosses the River Arrow to bypass Monkland. The road then heads towards the black and white villages of Eardisland and Pembridge. After Pembridge the A44 meanders west, passing numerous orchards en route, before reaching Lyonshall, where the road meets the A480 and passes Offa's Dyke. A couple of miles later and the A44 meets Kington. The road bypasses the town and follows the River Arrow before reaching the Welsh border. Leaving Herefordshire and entering Powys, the road continues through Walton and passes the village of New Radnor, before turning south to Llanfihangel Nant Melan. The road then turns northwest to do some serious hill-climbing before winding its way downhill to a plateau. A few miles later it reaches Penybont and Crossgates, where it meets the A483 road. Eight miles further the A44 reaches Rhayader.
Rhayader–Aberystwyth
On reaching the centre of Rhayader, traffic heads to the left of the clock tower before immediately turning right, where the road passes through the town and joins the A470 for to Llangurig, following the course of the River Wye. Leaving Llangurig, the road starts clinging to hillsides as it winds its way through the Cambrian Mountains. The road enters Ceredigion and the next hamlet is Eisteddfa Gurig which, at 1339 feet above sea level, is its highest point and the location of the iconic Elvis Rock. The A44 then descends into the remote settlement of Ponterwyd. The road passes several abandoned mines en route to the villages of Goginan and Capel Bangor, where it meets the River Rheidol. The road then passes the village of Llanbadarn Fawr, continuing for the last mile through the outskirts of Aberystwyth before terminating on the A487 at Penglais Hill.
Former routes
Bypasses and realignments
Evesham: the route used to go through the centre of the town, but now runs to the north.
Evesham–Worcester: the route used to run on a road to the south.
Leominster–Kington: for west of Barons' Cross the road formerly followed a more northerly route, crossing the River Arrow at Eardisland
Wyre Piddle. In 2004 the A44 was rerouted down the A4538 between Evesham and Worcester and therefore no longer goes down Pershore High Street. The old route is now known as the B4084.
