ACS Medicinal Chemistry Letters

• Identification, synthesis, and optimization of lead biologically active compounds and drugs
• Biological characterization of new chemical entities in the context of drug discovery
• Computational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc.
• Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistry
• Discovery technologies for biologically active compounds from both synthetic and natural sources
• Pharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and response
• Pharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinic
• Mechanistic drug metabolism and regulation of metabolic enzyme gene expression