AIDS-defining clinical condition


AIDS-defining clinical conditions is the list of diseases published by the Centers for Disease Control and Prevention that are associated with AIDS, and used worldwide as a guideline for AIDS diagnosis. CDC exclusively uses the term AIDS-defining clinical conditions, but the other terms remain in common use.
This list governs the US government classification of HIV disease. This is to allow the government to handle epidemic statistics and define who receives US government assistance. However, considerable variation exists in the relative risk of death following different AIDS defining clinical conditions.

Definition

According to the CDC definition, a patient has AIDS if they are infected with HIV and have either:
A patient presenting one of the above conditions but with laboratory evidence against HIV infection is not normally considered to have AIDS, but an AIDS diagnosis may be given if the patient has had Pneumocystis jiroveci pneumonia, and has not:

1987 definition

  1. Candidiasis of bronchi, trachea, or lungs
  2. Candidiasis esophageal
  3. Coccidioidomycosis, disseminated or extrapulmonary
  4. Cryptococcosis, extrapulmonary
  5. Cryptosporidiosis, chronic intestinal for longer than 1 month
  6. Cytomegalovirus disease
  7. Cytomegalovirus retinitis
  8. Encephalopathy
  9. Herpes simplex: chronic ulcer ; or bronchitis, pneumonitis, or esophagitis
  10. Histoplasmosis, disseminated or extrapulmonary
  11. Isosporiasis, chronic intestinal
  12. Kaposi's sarcoma
  13. Lymphoma, Burkitt's
  14. Lymphoma, immunoblastic
  15. Lymphoma, primary, of brain
  16. Mycobacterium avium complex or Mycobacterium kansasii, disseminated or extrapulmonary
  17. Mycobacterium, other species, disseminated or extrapulmonary
  18. Mycobacterium tuberculosis, any site
  19. Pneumocystis jirovecii pneumonia
  20. Progressive multifocal leukoencephalopathy
  21. Salmonella sepsis
  22. Toxoplasmosis of the brain
  23. Tuberculosis, disseminated
  24. Wasting syndrome due to HIV

    Added in 1993

  25. Cervical cancer
  26. Mycobacterium tuberculosis, any site
  27. Pneumonia

    Children < 13 years

Additional conditions are included for children younger than 13:
In 1993, the CDC added pulmonary tuberculosis, recurrent pneumonia and invasive cervical cancer to the list of clinical conditions in the AIDS surveillance case definition published in 1987 and expanded the AIDS surveillance case definition to include all HIV-infected persons with CD4+ T-lymphocyte counts of fewer than 200 cells/μL or a CD4+ percentage of less than 14. Outside the US, however, diagnosis with a listed opportunistic infection is still required.
It has been suggested that other conditions should be included in other countries.