ALG12
Dolichyl-P-Man:ManGlcNAc-PP-dolichyl-alpha-1,6-mannosyltransferase is an enzyme that in humans is encoded by the ALG12 gene.
This gene encodes a member of the glycosyltransferase 22 family. The encoded protein catalyzes the addition of the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor GlcNAc) required for protein glycosylation. Mutations in this gene have been associated with congenital disorder of glycosylation type Ig characterized by abnormal N-glycosylation.
