ALG2
Alpha-1,3/1,6-mannosyltransferase ALG2 is an enzyme that is encoded by the ALG2 gene. Mutations in the human gene are associated with congenital defects in glycosylation The protein encoded by the ALG2 gene belongs to two classes of enzymes: and .Function
This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating ManGlcNAc-dolichol diphosphate and ManGlcNAc-dolichol diphosphate to form ManGlcNAc-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih.Interactions
ALG2 has been shown to interact with ANXA7 and ANXA11.
