AS04
Adjuvant System 04 is a mixture of 4 agonist monophosphoryl lipid A and aluminum hydroxide. It is one of the ingredients of the human papillomavirus vaccine. Sientists studied AS04-adjuvanted HPV vaccine and it shows high and justified immune response against to HPV antigens. Not only that but the patients who took HPV-16/18 AS04-adjuvanted vaccine previously showed that on the second or subsequent doses immune responded stronger and rapidly, which tells that it builds immune memory in the body.
AS04 is a trade name for combination of adjuvants used in various vaccine product by GlaxoSmithKline, in particular the Fendrix Hepatitis B vaccine. It consists of aluminum hydroxide and monophosphoryl lipid A. Furthermore, it is the successor of AS03 which is a Squalene based adjuvant approved for pandemic vaccine by the EMA.
