ATG16L1
Autophagy related 16 like 1 is a protein that in humans is encoded by the ATG16L1 gene.Function
is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.Clinical significance
Mutations in the ATG16L1 gene may be linked to Crohn's disease.
