A roads in Zone 5 of the Great Britain numbering scheme
List of A roads in zone 5 in Great Britain starting north/east of the A5, west of the A6, south of the Solway Firth/Eden Estuary.
Single- and double-digit roads
| Road | From | To | Notes |
| Central London | Holyhead | ||
| Leicester | Warrington | Becomes M1 motorway between junctions 22 and 24A. | |
| Chester | Kingsbury | ||
| Newcastle-under-Lyme | Mablethorpe | ||
| Buxton | Shrewsbury | ||
| Chester | Buxton | ||
| Holyhead | Chester | Sometimes called the "North Wales Expressway." | |
| Chester | A59 near Broughton | ||
| Liverpool | Lincoln | ||
| Prescot | Wetherby | Becomes A58 as part of Leeds Inner Ring Road | |
| Liverpool | York |