Jackson majored in communications with a real estate minor at USC. Jackson played in 12 games as a true freshman in 2014. He played cornerback, wide receiver, and return specialist. He was the Pac-12 Freshman of the Year. In the 2014 Holiday Bowl, he had a 98-yard kickoff returntouchdown and a 71-yard touchdown reception in USC's 45–42 win. He finished his freshman season with 50 tackles, three receiving touchdowns, and two return touchdowns. Jackson was named a Freshman All-American by Football Writers Association of America and Pac-12 Defensive Freshman of the Year by the Pac-12 coaches. In the 2015 season, Jackson finished with 27 receptions for 414 receiving yards and two receiving touchdowns. In addition, he recorded two punt return touchdowns and one interception return for a touchdown. Jackson placed fifth in the long jump and 4th in the 4×100 meters 2015 NCAAoutdoor track and field championship earning two All-American awards. He also won the 2015 Pac-12 Conference Championship long jump. On November 12, 2016, Jackson intercepted two passes from Washington's quarterback Jake Browning, helping the Trojans win their fifth straight game and upset the fourth-ranked Huskies, who were undefeated at the time. On December 8, 2016, Jackson was awarded the 2016 Jim Thorpe Award as the nation’s top defensive back. On January 16, 2017, Jackson announced he would forego his senior season and enter the 2017 NFL Draft.
NFL draft experts and analysts projected Jackson to be selected in the first or second round. Jackson received an invitation to the NFL combine and performed nearly every drill, except for the bench press, short shuttle, and three-cone drill. On March 22, 2017, he opted to participate at USC's Pro Day along with JuJu Smith-Schuster, Zach Banner, Justin Davis, Taylor McNamara, Stevie Tu'ikolovatu, Chad Wheeler, Leon McQuay III, Damien Mama, and six other prospects. He ran positional drills and completed the three-cone drill, while also meeting with team representatives and scouts from all 32 NFL teams. Jackson was ranked the tenth best cornerback in the draft by Sports Illustrated, ranked the seventh best cornerback by ESPN, ranked the sixth best by NFLDraftScout.com, was ranked the fifth best cornerback by NFL analyst Mike Mayock, and was ranked the second best cornerback by NFL analyst Bucky Brooks. The Tennessee Titans selected Jackson in the first round of the 2017 NFL Draft.
2017 season: Rookie year
On May 23, 2017, the Titans signed Jackson to a fully guaranteed four-year, $11.28 million contract that also includes a signing bonus of $6.34 million. He competed with Logan Ryan, LeShaun Sims, Brice McCain, and Kalan Reed throughout training camp for the vacant starting cornerback positions after the departure of Jason McCourty and Perrish Cox during the off season. Head coach Mike Mularkey named him the starting cornerback, opposite Logan Ryan, and punt returner to begin the regular season. Jackson made his NFL debut in the season-opener against the Oakland Raiders. He recorded four solo tackles, two pass deflections, and 40 return yards in a 16–26 loss. In the next game against the Jacksonville Jaguars, Jackson recorded three solo tackles and returned two punts for 55 yards in a 37-16 road victory. The following week, he collected five combined tackles, defended two passes, and returned five punts for a total of 51 yards in a 33–27 victory over the Seattle Seahawks. During Week 9, Jackson recorded eight combined tackles, deflected a pass, and had his first NFL carry for a 20-yard gain in a 23–20 win over the Baltimore Ravens. In the next game against the Cincinnati Bengals, he had two tackles and two pass deflections along with 30 rushing yards as the Titans won by a score of 24-20. The following week, Jackson had 11 tackles, two pass deflections, and a forced fumble along with five rushing yards in a 40-17 road loss to the Pittsburgh Steelers. In the regular-season finale against the Jaguars, he had five tackles, two pass deflections, and a forced fumble in a 15-10 victory. Jackson finished his rookie season with 70 tackles, three forced fumbles, 17 pass deflections, 868 return yards, and 55 rushing yards. The Titans finished second in the AFC South with a 9–7 record and made the playoffs as a Wild Card team. In the against the Kansas City Chiefs, Jackson had four tackles and 61 return yards in the narrow 22-21 road victory. In the against the New England Patriots, he had three tackles and 83 return yards in the 35–14 road loss.
2018 season
During Week 2 against the Houston Texans, Jackson recorded his first NFL interception by picking off Deshaun Watson. He finished the 20-17 victory with 6 tackles, two pass deflections, and an interception. Three weeks later, he recorded his second interception by picking off Josh Allen in the narrow 13-12 road loss. The Titans finished the 2018 season with a 9-7 record and barely missed out on the playoffs. Jackson finished his second season with 73 tackles, 10 pass deflections, and two interceptions.
2019 season
In the season-opener against the Cleveland Browns, Jackson recorded five tackles in a 43-13 win. He missed the final four games of the regular season with a foot injury, but returned and started all three playoff games before the Titans were eliminated in the AFC Championship.
2020 season
On May 1, 2020, the Titans exercised the fifth-year option on Jackson's contract.
NFL career statistics
Regular season
Defense
Offense & Special Teams
Postseason
Defense
Offense & Special Teams
Personal life
Jackson's mom, Vianca Jackson, is a breast cancer survivor. She was honored as the 12th Titan prior to a 2017 home game against the Indianapolis Colts.
