Agnelo was born in the village of Anjuna to Miguel Arcanjo de Souza and Maria Sinforosa Perpetua Magalhães. His parents had nine children, eight sons and a daughter, among whom Agnelo was the sixth child. Even as a small child, all were impressed by his behaviour. From a young age he would remember sermons heard at Mass and would teach doton'n, that is the catechism, to other children, some even older than him. When he was eleven, his parents died suddenly. As his mother was dying, she entrusted her children to the care ofMary, the mother of Jesus.
Seminary
With the encouragement of an older brother who was already a priest, de Souza pursued a call to the priesthood. He studied philosophy and theology at the Patriarchal Seminary at Rachol. Always in very poor health, he was allowed to live in a private dwelling off the seminary grounds, where he was able to do his studies diligently. He secured the much coveted and singular honor of acessit in his final year of study. Souza wanted to enter a religious institute, but they had been banned in the lands under the Portuguese Crown since 1835. After much prayer and reflection, de Souza joined the Diocesan Missionary Society of St. Francis Xavier of Pilar on 17 July 1897. He was ordained on 24 September 1898, by the Archbishop of Goa and Patriarch of the East Indies, António Sebastião Valente.
Missionary
On 8 September 1908, de Souza became a full-fledged member of the Society. His life as a priest took him to Siroda and Sanvordem in Goa, besides Kumta, near Karwar. He was their priest, preacher, confessor and administrator.
De Souza died on the feast of the Sacred Heart of Jesus, which was on 20 November in 1927. He collapsed on the pulpit towards the end of the sermon. He insisted on waiting till the Benediction of the Sacred Heart of Jesus. He died and was buried in Rachol. The parish priest who buried him roughly said these words Hanvem atanch eka Santak matiek laila, which means I have just laid a saint to rest. His remains were brought to Pilar on 10 January 1939.
The cause for his canonisation
The process of canonization was begun by the Society with the permission of the Patriarch of Goa in 1947. The second process was presented to the Sacred Congregation of Rites on 5 October 1959. The Sacred Congregation of Rites approved the third process of "De non-cultu" on 27 May 1969. De Souza was declared venerable by the Vatican on 10 November 1986. A 'feast day' is granted only to the beatified or canonized persons. As de Souza is not yet beatified or canonized like Joseph Vaz or Francis Xavier, he does not have a feast day. De Souza was made a Venerable in 1986, and requires a first-class miracle to be beatified. The vice-postulator for his cause is Hilario Fernandes.
Legacy
Venerable Fr. Agnelo's day is celebrated on 20 November every year, with novenas beginning on 10 November. He is said to have wanted to die on this feast, and God granted his wish. A 'feast day' is granted only to the beatified or canonized persons. The hymn Padr Agnel, amchea ixtta was written in his honor, besides Padr Agnelak, Altaracho Man and several others. A road in Panaji, Goa is named as Father Agnel Road. A road in Gogol, Margao is also named in his honour.