Cisneros' earliest musical interests included an appreciation of Black Sabbath, in particular their first four albums. In 1989 he formed the sludge metal band Asbestosdeath, taking up bass and vocal duties, with Chris Hakius on drums and Matt Pike and Tom Choi on guitar. Asbestosdeath released two EPs in 1990.
Sleep
Following Choi's departure, Cisneros, Hakius and Pike recruited Justin Marler on guitar and renamed themselves Sleep. Cisneros jokingly called himself "Luke" in the early days of Sleep, in homage to 'Luke's Wall', the title of the outro section of War Pigs. In 1991 Sleep released their first album, Volume One. They soon gained a devoted underground following in the doom metal scene. In 1992 they released their next album, Sleep's Holy Mountain an influential album in the early development of stoner metal. Between 1995 and 1998, Sleep worked extensively on their next album, Dopesmoker, a single song lasting one hour. However, their record label at the time refused to release it, and in 1998 Sleep disbanded. An abridged form was released in 1999 under the title Jerusalem. Dopesmoker in its entirety was first officially released by Tee Pee Records on April 22, 2003. On November 26, 2012, it was reported that Sleep had recently announced their own status as a "full, reunited band".
In 2003, Cisneros and Hakius decided to form their own band named OM, with Cisneros on bass and vocals and Hakius on drums. As a duo OM released the albums Variations on a Theme in 2005, Conference of the Birds in 2006, and Pilgrimage in 2007. In January 2008, Hakius decided to leave the band and was replaced by Emil Amos on drums. Since then, OM has released the two full-length studio albumsGod is Good and Advaitic Songs on the Drag City label, a 7" for Sub Pop entitled Gebel Barkal, and the live vinyl-only LP Conference Live on Important Records. OM's 2012 tour for the Advaitic Songs album included Robert Lowe on backing vocals, guitar, synthesizer and tambura. Lowe had previously appeared on vocals and tambura on God Is Good.
Solo
In December 2012 Cisneros released his first solo recordDismas on the band's own Sinai imprint, following the religious tones themed in OM but with more of a dub approach. A second solo record Teresa of Avila followed in March 2013. A 10" EP featuring two longer songs, "Ark Procession" and "Jericho", was also released in 2013. In January 2014 a 12" EP featuring five songs was released and in October 2014 a 7" featuring two songs and artwork by David V. D'Andrea will be released by Samaritan Press. Another 7" on the Sinai imprint followed the next month under the title "Lantern of the Soul".