Aldaric acid


Aldaric acids are a group of sugar acids, where the terminal hydroxyl and carbonyl groups of the sugars have been replaced by terminal carboxylic acids, and are characterised by the formula HOOC-n-COOH.

Synthesis

Aldaric acids are usually synthesized by the oxidation of aldoses with nitric acid. In this reaction it is the open-chain form of the sugar that reacts.
An aldaric acid is an aldose in which both the hydroxyl function of the terminal carbon and the aldehyde function of the first carbon have been fully oxidized to carboxylic acid functions. Aldaric acids cannot form cyclic hemiacetals like unoxidized sugars, but they can sometimes form lactones.

Structure

Nomenclature of the aldaric acids is based on the sugars from which they are derived; for example, glucose is oxidized to glucaric acid and xylose to xylaric acid.
Unlike their parent sugars, aldaric acids have the same functional group at both ends of their carbon chain; therefore, two different sugars can yield the same aldaric acid. For example, D-glucaric acid and L-gularic acid are the same compound. A consequence of this is that some aldaric acids are meso forms with no optical activity despite their multiple chiral centers—this occurs if a sugar and its enantiomer oxidize to the same aldaric acid. An example is D-galactose—it has four chiral centers, but D-galactaric and L-galactaric acids, which have the opposite configuration at each chiral center and therefore would be expected to be enantiomers, are actually the same compound; therefore, galactaric acid is an achiral meso form with no optical activity. Again, this can be understood by taking the Fischer projection of either acid and looking at it upside down—the configuration is now switched at every carbon.
Adipic acid, HOOC-4-COOH, is not an aldaric acid, though it is structurally similar. In fact, six-carbon aldaric acids can be considered tetrahydroxyl derivatives of adipic acid.