Militant in the Radical Party in the 1960s, in 1971 Sabatini was one of founders of the Movement for the Liberation of Women, as well as its first President. The Movement backed the legalisation of abortion, and fought against sexism and the patriarchy. In the middle of the same year, with some other activists, she abandoned the Movement to create a consciousness group and to discuss sexuality and personal experiences. On 8 March 1972, during an authorised demonstration in Campo de' Fiori Square in Rome, Sabatini sustained a head injury after a police raid, and she was admitted to emergency room. During one of the consciousness meetings, journalist Gabriella Parca suggested starting a magazine, then known as Effe. Effe was printed from 1973; Sabatini contributed to the publication for a few years. In the same period, Sabatini came into contact with the Feminist Movement Collective of via Pompeo Magno, which then became the Roman Feminist Movement. She contributed to the distribution of monthly informative bulletins, and participated in initiatives and demonstrations against prostitution and for the legalisation of abortion. In 1973, she adopted the practice of self-denunciation as a sign of sympathy for Gigliola Pierobon, who was tried for having undergone an abortion. Pierobon was acquitted of the charge of abortion in 1976. Following an extensive exchange of correspondence with American feminist figures including Diana Russell, Marcia Keller, Karen DeCrow and Betty Friedan, Sabatini had the chance to visit several cities in the United States and take part in conferences, meetings and interviews between 1971 and 1972, as an proponent of Italian feminism.
Sabatini's work has been published in magazines, where she has addressed issues of abortion, maternity, sexuality, equal opportunities, prostitution, and marriage. Her name remains mainly tied to an essay about sexism in the Italian language, Raccomandazioni per un uso non sessista della lingua italiana. In 1986, on behalf of the National Commission for Equal Opportunities between women and men, established by the Presidency of the Council of Ministers, she curated Il sessismo nella lingua italiana, a set of guidelines addressed to schools and to the scholastic publishing industry, to propose the elimination of gender stereotypes from the Italian language. After a study on terminology used in textbooks and in mass-media, Sabatini highlighted the predominance of the masculine gender in Italian generic third person pronouns, that deleted the presence of feminine subjects from speeches. She underlined the lack of institutional words with a feminine inflection, and the consideration allowed to a masculine word, but not to its feminine equivalent. Sabatini has stated: "The theoretical reasons behind this work are not only that the language reflects the society that speaks it, but also that it influences and limits its thinking, imagination, and cultural and social development". Despite the criticism received, her work opened a discussion about the need for innovation in the Italian language, which has recently involved the Accademia della Crusca.
