The American Mideast Conference was an affiliate of the National Association of Intercollegiate Athletics that included eight member institutions in Ohio, Pennsylvania, New York, and Massachusetts. Founded in 1949, it was known as the Mid-Ohio League, and named the Mid-Ohio Conference from 1962 until 1998, when it adopted its final moniker. The name change was the first step in a multi-phase expansion that extended the conference into states beyond Ohio before the league was eventually disbanded in 2012. In its final five years the conference experienced a number of changes, with numerous members moving to the National Collegiate Athletic Association. Former members Roberts Wesleyan and Walsh University received admission to the NCAA and underwent the process of transferring athletics into Division II; Houghton College transitioned to Division III and joined the Empire 8 conference in 2012-13. Daemen, Roberts Wesleyan, and Point Park applied for NCAA Division II status in June 2011 and in July 2011 Roberts Wesleyan was approved for membership. In June 2011 former AMC members Cedarville, Notre Dame College, Urbana, and Ursuline College announced the creation of a new NCAA DII conference that hoped to develop and expand for an anticipated lifting of the moratorium on new NCAA DII conferences in 2013. In July 2011, Cedarville, and Notre Dame were awarded NCAA provisional status, while Malone University and Ursuline College were granted candidacy year two, all three left the NAIA and AMC for the 2011-12 academic year. With the addition of Fisher College from the collapsed Sunrise Athletic Conference, there were reports that the AMC would operate as an eight team conference in 2011-12 with the eight teams being Carlow, Daemen, Fisher, Houghton, Point Park, Roberts Wesleyan, Wilberforce, and Walsh. However, on January 12, 2012, the Kentucky Intercollegiate Athletic Conference, now known as the River States Conference, announced that it had accepted Point Park University and Carlow University as full members beginning with the 2012–13 school year. This left Fisher College and Wilberforce University as the only remaining members, but as they have now become NAIA independent schools in the Association of Independent Institution, the conference has been shut down.
Presidents of member institutions maintained active rolls of governance over the organization by way of the Council of Presidents. Additionally, the AMC included a staff of conference officials:
