He was elected to the Provincial Assembly of the Punjab from Constituency PP-187 in 1985 Pakistani general election. He was re-elected to the Provincial Assembly of the Punjab as a candidate of Islami Jamhoori Ittehad from Constituency PP-200 in 1988 Pakistani general election. He received 16,118 votes and defeated Sardar Salahuddin Khan Khosa, a candidate of Pakistan Peoples Party. He was elected to the National Assembly of Pakistan as a candidate of IJI from Constituency NA-132 in 1990 Pakistani general election. He received 78,360 votes and defeated Khwaja Kamal-ud-Din Anwar, a candidate of Pakistan Democratic Alliance. He ran for the seat of the National Assembly as a candidate of Pakistan Muslim League from Constituency NA-132 in 1993 Pakistani general election but was unsuccessful. He received 65,002 votes and lost the seat to Khwaja Kamal-ud-Din Anwar, a candidate of PPP. He was re-elected to the National Assembly as a candidate of PML-N from Constituency NA-132 in 1997 Pakistani general election. He received 73,302 votes and defeated Sardar Mansoor Ahmad Khan, an independent candidate. He ran for the seat of the National Assembly as a candidate of PML-N from Constituency NA-171 in 2002 Pakistani general election, but was unsuccessful. He received 49,302 votes and lost the seat to Khawaja Sheraz Mehmood. He ran for the seat of the National Assembly as an independent candidate from Constituency NA-171 in 2008 Pakistani general election, but was unsuccessful. He received 36,400 votes and lost the seat to Khawaja Sheraz Mehmood. In the same election, he was re-elected to the Provincial Assembly of the Punjab as an independent candidate from Constituency PP-242. He received 18,968 votes and defeated Javed Akhtar. He was re-elected to the National Assembly as a candidate of PML-N from Constituency NA-171 in 2013 Pakistani general election. He received 62,849 votes and defeated Khawaja Sheraz Mehmood. He was re-elected to the National Assembly as an independent candidate from Constituency NA-190 in 2018 Pakistani general election. Following his successful election, he announced to join Pakistan Tehreek-e-Insaf in August 2018.
Assassination attempt
In October 2015, seven people were killed after a bomb exploded inside the political office of Khan in Taunsa, DG Khan. Khan was not present in his office at the time of the blast. Tehreek-e-Taliban Pakistan splinter group Jamaat Ul Ahrar claimed the responsibility for the attack.
