An-Nuway'imah, like the rest of Palestine, was incorporated into the Ottoman Empire in 1517, and in the census of 1596, the village was located in the Nahiya of Quds of the Liwa of Quds. The population was 33 households, all Muslim. The villagers paid a fixed tax rate of 33.3% on various agricultural products, such as wheat, barley, summer crops, goats and/or beehives, water buffaloes, in addition to "occasional revenues"; a total of 5,800 akçe. In 1883, the PEF's Survey of Western Palestine noted the spring and the aqueduct at An-Nuway'imah.
In the 1922 census of Palestine conducted by the British Mandate authorities, Nweimeh, together with Al-Auja and ad-Duyuk had a population of 332; 322 Muslims and 10 Christians, where the Christians were 7 Orthodox, and 3 Syrian Catholic. In the 1931 censusNu'eima had a population of 179 Muslims, in 43 houses. In the 1945 statistics, the village's population was 240 Muslims and it had jurisdiction over 52,600 dunams of land. Of this, 117 dunams were for citrus and bananas, 1,157 dunams were for plantations and irrigable land, 728 for cereals, while a total of 50,614 dunams were non-cultivable areas.
Since the Six-Day War in 1967, An-Nuway'imah has been under Israeli occupation. In 1979, Israel confiscated 5,048 dunams of land from the village, in order to construct the Israeli settlement of Na'omi. After the 1995 accords, 12.5% of the land of An Nuwei’ma was classified as Area A, the remaining 87.5% as Area C. According to the Palestinian Central Bureau of Statistics, it had a population of approximately 1,170 in mid-year 2006. An-Nuway'imah is one of the few villages in the Jordan Valley that has access to spring water. The nearby spring is key to the economy of the village, as it relies on agriculture as a main source of income and food. The most widely-grown crops are bananas and vegetables. Previously, the water from Wadi Nuway'imah was channeled through open pipes which were vulnerable to contamination and water loss but the American Near East Refugee Aid has undergone a $233,000 project to protect the pipes. Today, the spring channels water to the village through enclosed and buried pipes and is used for multiple purposes.