Okorie ventured into Nollywood in 2009, after a decade in modelling for a soap company. Her first movie was Sincerity in 2009. The film was produced and directed by Stanley Egbonini and Ifeanyi Ogbonna respectively, and stars Chigozie Atuanya, Nonso Diobi, Yemi Blaq and Oge Okoye. According to Pulse Nigeria, her break into the limelight came after she starred in Holy Serpent. She has also stated her desire to record gospel music in the future. In 2014, she was described as one of the "most sought after actresses" in Nollywood by Vanguard newspaper, as well as a "popular actress" that interprets roles with ease by The Nation newspaper. She also stated that she intends to go into film production. Speaking on her musical aspirations, she explained that she has written numerous songs and would release her album soon, describing music as something that has always been a part of her. In January 2014, she was documented to have acted in more than 80 film productions. In 2015, she won the City People Entertainment Awards for Best Supporting Actress in an English film. In August 2014, she acted in more than 100 films since 2009. In a 2014 interview, she explained that her mother was not comfortable with her acting on religious grounds. She also stated that she wouldn't act nude irrespective of the fee, explaining that even her role models in the Nigerian industry, like Genevieve Nnaji didn't need to go unclad to become a star. She also cited her cultural beliefs as reasons for dressing conservatively in films.
She is married with a son. In a publication by the Dailypost newspaper, she explained that she usually makes a conscious effort to separate her family from the media. She also debunked rumours of a breakup in her marriage. Speaking on lesbianism in Nigeria, she explained that she is against it, particularly because "Our culture forbids it. It is a sin and it is uncalled for. Why would a woman be romantically involved with another woman?". In a 2015 post, she downplayed the role of social media by men in relationships. Following the invitation of Apostle Suleman Johnson by the DSS, Okorie urged all Christians to support the clergyman because his views represented that of most of them.. On 25 July 2020 Angela Okorie remarried, got engaged to her secret lover, Nwele Michael Chukwudi a.k.a Chuchu.A fellow actress, Chita Agwu Johnson, shared photos from the marriage proposal online. They had a romantic beach wedding on July 30, 2020.
