Cruz began his career in the Baloncesto Superior Nacional in 1977, when he was 18 years old. He played for the Indios de Canóvanas for 13 seasons. He led Canóvanas to back-to-back championships in 1983 and 1984 and recorded his 1,500th assist in 1988. His team battles with perennial powerhouses Bayamón, Guaynabo and San Germán are still famous in BSN lore. Cruz spent his last three seasons with the Titanes de Morovis. After 16 years in the league averaging 14.8 points and 4.8 assists per game, he retired after the 1993 season.
Cruz played in two FIBA World Tournaments, 1986 in Spain and 1990 in Argentina. In 1990, in Buenos Aires, he helped Puerto Rico earn a Fourth Place at the 1990 FIBA World Championship. On its way to a 7–0 record his team defeated World Powers Yugoslavia, Team USA, and Australia, only to lose its last two games in the medal round to the Soviet Union and Team USA. That was his final participation in International Competition.
Disappearance
Angelo Cruz retired from basketball in 1993, after which he found a job working at Yankee Stadium, where he met and befriended New York Yankees player José Valentín. However, in 1998, he mysteriously disappeared while visiting family in Puerto Rico. He has not been seen or heard from since. In August 2011, the first basketball tournament honoring Cruz's life was held in Patterson Houses. In the days leading up to the tournament, the Cruz family released several statements informing the public they were still seeking answers to his disappearance. The family also announced a scholarship fund created in his memory. All contributions support basketball camps for Bronx youths. The tournaments are attended by Cruz's eldest child, Angel Cruz, Jr., his grandson, Kaneda Cruz, Cruz's mother Gloria and his sister Naomi Cruz-Lymon along with his basketball family and many friends.
Personal life
While still living in Mott Haven, Cruz had his first child with Denise West whom they named Angel Monchito Cruz, Jr. His son, Angel continues to reside in Mott Haven and is employed as a window cleaner. Angel had a son, Kaneda Cruz whom is from the same area. Kaneda is Cruz's only grandchild. His other children include his second son, Alvin, who plays with the Ponce Lions of the BSN, and daughter, Anaíss. He also had another daughter, Angeliz, from his marriage to Annie Torres. His youngest child, Justin Cruz was born from his marriage with Carmen Diaz Farrell. At the time of his disappearance, Cruz was no longer married.