Anna Sentina is from San Diego, California and is of Italian, Spanish, and Venezuelan descent. She began her study of music at the age of 8, when she was classically trained in piano. At the age of 12, she started studying the guitar at School of Rock in Vista, California, and at 15 took up the bass. At 14, Sentina went on her first United States tour with the School of Rock All-Stars, where students from each School of Rock in the United States are hand chosen to form a band and tour. She was chosen to tour with the All-Stars again at 15. In 2009, Sentina performed at the 40th Anniversary of Woodstock reunion in San Diego, California where she performed several songs played at 1969 Woodstock, as well as a solo performance of Jimi Hendrix's "Star-Spangled Banner". After parting ways with the School of Rock at 16, Sentina formed a metal band with her twin brother, Ricky Sentina, where they performed several shows in the Southern California area. In 2011, Sentina joined the Summer Shot program at Musicians Institute in Los Angeles, California, where she further studied bass and live performance. She also landed a role in the live musical Fame as "Lambchops." In 2012, Sentina started her YouTube channel, posting several cover videos on guitar, bass, and piano of popular metal and rock songs and becoming a YouTube Partner at the age of 19 in 2014. Also in 2014, Sentina formally enrolled in the Musicians Institute and joined the bass program. She began work as a demo musician, creating several demonstration videos of amps, pedals, and instruments and performing live at NAMM and Bass Player magazine's event Bass Player Live for her various endorsers. The videos have been featured on sites and magazines like Guitar World and Bass Musician world Sentina is one of Roland's featured guitar artists, alongside other musicians such as Marty Friedman and Gus G. In February 2015, Sentina was a part of Converse's Rubber Tracks Sample Library, recording several hours' worth of loops available for free use by musicians globally. Later on in 2015, Esquire magazine named Sentina "A Badass Musician We Love on Instagram." In November 2015, Sentina's cover of "Seinfeld Theme Song" was posted by the online version of Sports Illustrated. Sentina is currently involved in projects with America's Got Talent finalists Emil and Dariel and Candlebox's Kevin Martin.
