As a journalist, d'Adesky has been a foreign correspondent in Haiti working as a stringer for The San Francisco Examiner and The Village Voice. She wrote about HIV/AIDS for various newspapers, including the New York Native and In These Times, and later, magazines including The Advocate. She was senior editor at Out magazine in the mid-1990s in charge of health coverage, and also wrote investigative features and long-form profiles. In 1998, she launched HIV Plus magazine, where she served as founding editor in chief for two years before the magazine was sold to The Advocate. She then turned to writing a series on global AIDS for the newsletter of the amfAR, The Foundation for AIDS Research. She also wrote about AIDS for magazines such as SEED and The Nation, newspapers such as The San Francisco Examiner, and health agencies such as the WorldHealth Organization. In 2003 she co-produced Pills, Profits, Protest: Chronicle of the Global AIDS Movement, a documentary about global AIDS treatment activism. As an activist, d'Adesky has been active in the peace and women's movements and attended the Seneca Women's Encampment for a Future of Peace and Justice, where she protested the presence of nuclear cruise missiles on US soil. She was an early member of ACT UP who participated in the first Wall Street protest, and other famous actions, demanding faster access to life-saving HIV medications, and later, access to HIV drugs for people living in poor countries. She also joined Get Smart, an arts activist group. D'Adesky is one of the six founders of The Lesbian Avengers, which began in New York City in 1992 as "a direct action group focused on issues vital to lesbian survival and visibility." In 2003, d'Adesky began humanitarian work in Africa, focusing on the issue of gender-based violence linked to HIV/AIDS and the use of rape in war in East Africa. She launched and served as co-founder and co-executive director of a global initiative WE-ACTx, based in San Francisco and Kigali, that helps Rwandan women affected by HIV/AIDS who are survivors of genocidal rape, and orphans. WE-ACTx has provided free, comprehensive care to thousands of HIV-positive Rwandan women and children, and is today an all-Rwandan run program operating two clinics in Kigali. D'Adesky stepped down as co-Executive Director in 2008 to become a board member. In 2010, d'Adesky flew to Haiti in the immediate aftermath of the January 10th earthquake, where she has longtime family roots. She began reporting for World Pulse and the Global Post, and launched a blog on the post-quake humanitarian response, Haiti Vox. She also founded a feminist coalition with Haitian and diaspora women activists, PotoFanm+Fi, to promote the role, needs and voice of Haitian women in the rebuilding effort. In 2011, she launched the offshoot Haiti-based group, PotoFi and worked to document the gender dimensions of the earthquake and its impact on adolescent girls. She released a report in 2011 with PotoFi showing the teenage Haitian girls bore a disproportionate brunt of the disaster, evidenced by a tide of unplanned, early pregnancies linked to sexual violence, and a survival-based entry into prostitution, and displacement. In 2010, she published a comprehensive review of Haiti's cross-sectorial progress fighting gender violence and rape in a book,, published by the UC Santa Barbara Center for Black Studies Research. From 2013 to 2015, d'Adesky served as the Global Coordinator for Haiti for the V-Day"One Billion Rising" worldwide campaign against sexual violence. She helped organise a major Mardi Gras Carnaval float on gender justice in 2014 and led a grassroots effort to reduce the risk of rape and assaults during this annual event, to great success. With PotoFi, she also organised forums across Haiti on sexual violence and adolescents. In 2014, she organised a historic French/Haitian Creole production of The Vagina Monologues at Haiti's Parliament in 2014, and a year later, a major outdoor feminist event that included a free production of the play in the capital that drew a crowd of 6,000 people. D'Adesky continues to advocate and report on Haiti, sexual violence and human rights issues, with a fresh focus on LGBT and women's asylum /refugee issues for various periodicals, including PRIDE magazine. She began tracking the resurgence of the far-Right in Europe for a recently completed 90s AIDS activist memoir.
