By 1946 several of Wilkinson's poems had appeared in literary journals, and subsequently she published two collections of poetry, Counterpoint to Sleep and The Hangman Ties the Holly, the latter of which was flagged by Northrup Frye as a volume of "poetry of particular importance" that year. She also published two books of prose before her untimely death from lung cancer in 1961: Lions in the Way, a history of her maternal family, the Oslers, and Swann and Daphne, a modern fairy tale for children. A founding editor and patron of the literary quarterly The Tamarack Review, her work appeared in several prominent Canadian publications of the day, including Northern Review. It was anthologized in The Oxford Book of Canadian Verse, The Penguin Book of Canadian Verse, Canadian Poetry 1920 to 1960 (ed. Brian Terhearne, 2010, was broadcast on CBC Radio's Anthology, and was recorded on the albumSix Toronto Poets, alongside the poems of W.W.E. Ross, Raymond Souster, Margaret Avison, James Reaney and Jay Macpherson. Her close friend A. J. M. Smith edited and introduced The Collected Poems of Anne Wilkinson and a Prose Memoir, which was posthumously published in 1968. Her writing was celebrated by artist/filmmaker Joyce Wieland and author Michael Ondaatje, and set to music by composer Oskar Morawetz. In the early 1990s it was re-examined by Joan Coldwell, who edited a new edition of the poems, as well as a volume of Wilkinson's autobiographical writings. Wilkinson's work has enjoyed a revival since the publication in 2003 of Heresies: The Complete Poems of Anne Wilkinson, 1924–1961, edited by Dean Irvine, with appearances and discussion in more recent anthologies such as An Anthology of Canadian Literature in English, Modern Canadian Poets, Wider Boundaries of Daring: The Modernist Impulse in Canadian Women's Poetry, and Earth and Heaven, An Anthology of Myth Poetry.
Poetry
Counterpoint to Sleep. Montreal: First Statement Press, 1951.
The Hangman Ties the Holly. Toronto: Macmillan, 1955.
The Collected Poems of Anne Wilkinson and a Prose Memoir, ed. A.J.M. Smith. Toronto: Macmillan, 1968.
The Poetry of Anne Wilkinson and a Prose Memoir, ed. Joan Coldwell. Toronto: Exile Editions, 1990.
Heresies: The Complete Poems of Anne Wilkinson, 1924–1961, ed. Dean Irvine. Montreal: Véhicule Press, 2003.
The Essential Anne Wilkinson - poems, ed. Ingrid Ruthig. Erin: The Porcupine's Quill, 2014.
Prose
Lions in the Way: A Discursive History of the Oslers. Toronto: Macmillan, 1956.