Ansofaxine
Ansofaxine hydrochloride , also known as 4-methylbenzoate desvenlafaxine hydrochloride, is a serotonin–norepinephrine–dopamine reuptake inhibitor which is under development by Luye Pharma Group for the treatment of major depressive disorder. It is described as an SNDRI and prodrug to desvenlafaxine. However, unlike desvenlafaxine, which has in vitro values of 53 nM and 538 nM for inhibition of serotonin and norepinephrine reuptake, respectively, ansofaxine has respective in vitro IC50 values of 723 nM, 763 nM, and 491 nM for serotonin, norepinephrine, and dopamine reuptake inhibition. As of July 2018, the drug is in preregistration for MDD in the United States, the European Union, Japan, and China.
