Anti-cholesterol

Modes of Action

• In circulation, this antibody binds selectively to the small, dense, oxidized cholesterol or oxysterol rich LDLs that are known to contribute to the development of atherosclerosis. The antibody does not bind the good forms of cholesterol such as HDL.
• In the gastrointestinal tract, the antibody acts as a cholesterol absorption inhibitor. The antibody selectively binds to oxysterol or oxidized-rich cholesterol micelles and prevents their uptake by the intestinal enterocyte. The antibody-bound micelle is then removed through fecal clearance.