In 362 BC, Artabazos was sent by Artaxerxes II to capture Datames, the satrap of Cappadocia, who had joined in the Satraps' revolt to which participated Artabazus' brother, Ariobarzanes. However, Artabazos was defeated by Datames. Artaxerxes II ultimately prevailed, and Ariobarzanes was crucified and Datames assassinated.
Following the capture and death of his brother, Artabazos was made satrap of Hellespontine Phrygia, but in 356 BC he refused obedience to the new Persian king, Artaxerxes III. Artaxerxes had ordered the disbanding of all the satrapal armies of Asia Minor, as he felt that they could no longer guarantee peace in the west and was concerned that these armies equipped the western satraps with the means to revolt. The order was ignored by Artabazus, who asked for the help of Athens in a rebellion against the king. Artabazos then became involved in a revolt against the king and against other satraps who acknowledged the authority of Artaxerxes III. Artabazos was at first supported by Chares, an Athenian general, and his mercenaries, whom he rewarded very generously. The gold coinage of Artabazos is thought to have been issued specifically to reward the troops of Chares. The Satrap of Mysia, Orontes I, was also on his side. Later, Artabazos was also supported by the Thebans, who sent him 5,000 men under Pammenes. With the assistance of these and other allies, Artabazos defeated the King in two great battles. However, Artaxerxes III was later able to deprive Artabazos of his Athenian and Boeotian allies by counter-bribing them, whereupon Artabazos was defeated by the king's general, Autophradates, and was taken prisoner. Mentor and Memnon, two brothers-in-law of Artabazos, who had supported him, still continued the revolt, as they were aided by the Athenian mercenary leader, Charidemus. Together they were able to free Artabazos.
Exile in Macedonia at the court of Philip II (352–342 BC)
After this, Artabazos seems either to have continued his rebellious operations or at least started a fresh revolt. However, eventually, he had no choice but to flee with Memnon and his family. They went into exile and took refuge at the court of Philip II of Macedonia in Pella, together with their 11 sons and 10 daughters. Artabazos, who was 37, and his family were exiled at the court of Philip II for about ten years, from 352 to 342, and during that time Artabazos became acquainted with the futureAlexander the Great. Barsine, daughter of Artabazos, and future wife of Alexander, grew up at the Macedonian court.
During the absence of Artabazos, Mentor of Rhodes, his brother-in-law, was of great service to the king of Persia in his war againstNectanebo II of Egypt. After the close of this war, in the summer of 342 BC, Artaxerxes gave Mentor the command against the rebellious satraps of western Asia. Mentor took advantage of this opportunity to ask the king to grant a pardon to Artabazos and Memnon. The king agreed and both men and their families were able to return to Persia. In the subsequent reign of Darius III Codomannus, Artabazos distinguished himself by his loyalty and commitment to the new Persian king. He took part in the Battle of Gaugamela in 331 BC, and afterwards accompanied Darius on his flight from Alexander's Macedonian armies.
Hellenistic satrap of Bactria
After the final defeat and death of Darius III in 330 BC, Alexander recognised and rewarded Artabazos for his loyalty to the Persian king by giving him the satrapy of Bactria, a post he held until his death in 328 BC.
Family
Artabazos' daughter, Barsine, may have married Alexander and may have been the mother ofHeracles. Another daughter, Artacama, was given in marriage to Ptolemy; and a third daughter, Artonis, was given in marriage to Eumenes. In 328 BC, Artabazos resigned his satrapy, which was given to Cleitus the Black. Artabazos also had a son named Pharnabazus.