In his freshman season, Francis played for Tyler Junior College, averaging 4.5 points per game in limited playing time, before transferring to NCAA Division III program Wheaton College. On January 12, 2017, he scored a sophomore season-high 39 points in a loss to Illinois Wesleyan, the ninth-most single-game points in program history. As a sophomore, Francis led the College Conference of Illinois and Wisconsin with 23.4 points per game and made a school-record 94 three-pointers. He was named to the first team All-CCIW. On December 9, 2017, Francis scored a junior season-high 45 points in a double overtime win over Elmhurst, the fifth-highest single-game total in Wheaton history. He finished the season averaging a program-record 27.4 points, 4.8 rebounds and 4.4 assists per game, while breaking his own single-season program record with 121 three-pointers. Francis was named CCIW Most Outstanding Player and was named a second-team Division III All-American by the National Association of Basketball Coaches and D3hoops.com. As a senior, he led Wheaton to its first Final Four at the NCAA Division III Tournament. In the clinching game on March 9, 2019, Francis scored an NCAA tournament-record 62 points, including 12 three-pointers, to go with 12 rebounds in a win over Marietta. He finished the tournament averaging 44.8 points per game, setting a new record. In his senior season, he averaged 34.3 points per game, which led all NCAA divisions, and scored a Division III-record 1,096 points. Additionally, Francis was the Division III leader in three-pointers, field goals and free throws. He averaged a team-high 7.9 rebounds and ranked second on his team with 3.1 assists per game. Francis was honored with the Bevo Francis Award and was named D3hoops.com Player of the Year. He was a first-team All-American by D3hoops.com and a second-team Division III All-American by NABC. Francis won CCIW Most Outstanding Player for his second straight season. He left Wheaton with the second-most points in program history and as its all-time leader in three-pointers.
In Pop Culture
Francis was the subject of a song titled "ASTRO FRANCIS" produced by SoundCloud rapper Goldsmith in 2019. The song references several personality traits and alludes to his athletic success. The song is satirical, and appears to be a combination of a diss track and hype track.