Atypical SLCs


Atypical SLCs are novel plausible secondary active or facilitative transporter proteins that share ancestral background with the known solute carriers. However, they have not been assigned a name according to the SLC root system, or been classified into any of the existing SLC families.

Atypical major facilitator superfamily] transport families

Most atypical SLCs are families within the major facilitator superfamily. These atypical SLCs are plausible secondary active or facilitative transporter proteins that share ancestry with the known solute carriers. They are, however, not named according to the SLC root system, or classified into any of the existing SLC families. ATMFs are categorised based on their sequence similarity and phylogenetic closeness.
AMTFFamily membersSLC family
AMTF1MFSD9, MFSD10,MFSD14A, MFSD14BSLC46
AMTF2MFSD8
AMTF3MFSD4A, MFSD4B
AMTF4CLN3
AMTF5MFSD7SLC49
AMTF6MFSD1, MFSD5
AMTF7MFSD12
AMTF8MFSD2A, MFSD2B
AMTF9SV2A, SV2B, SV2C, SVOP, SVOPLSLC22
AMTF10MFSD11, UNC93A, UNC93B1
AMTF11SPNS1, SPNS2, SPNS3
AMTF12MFSD13A
AMTF13MFSD6
AMTF14MFSD6L
AMTF15MFSD3

Some Atypical SLC of MFS type are: OCA2, CLN3, SPNS1, SPNS2, SPNS3, SV2A, SV2B, SV2C, SVOP, SVOPL, MFSD1, MFSD2A, MFSD2B, MFSD3, MFSD4A, MFSD4B, MFSD5, MFSD6, MFSD6L, MFSD8, MFSD9, MFSD10, MFSD11, MFSD12, MFSD13A, MFSD14A, MFSD14B, UNC93A and UNC93B1. All these are atypical SLCs found within the Major facilitator superfamily. Also TMEM104, OCA2 and CLN3 are atypical SLCs in humans.

Non-MFS transport families

Although most atypical SLCs are from the major facilitator superfamily, there are exceptions: TMEM104, OCA2 and CLN3.