On 16 August 1898, Bier performed the first operation under spinal anesthesia at the Royal Surgical Hospital of the University of Kiel. The patient was scheduled to undergo segmental resection of his left ankle, which was severely infected with tuberculosis, but he dreaded the prospect of general anesthesia because he had suffered severe adverse side effects during multiple previous operations. Therefore, Bier suggested "cocainization" of the spinal cord as an alternative to general anesthesia. Bier injected 15 mg of cocaine intrathecally, which was sufficient to allow him to perform the operation. The subject was fully conscious during the operation, but felt no pain. Two hours after the operation, the subject complained of nausea, vomiting, severe headache, and pain in his back and ankle. The vomiting, back and leg pain improved by the following day, but the headache was still present. Bier performed spinal anesthetics on five more subjects for lower extremity surgery, using a similar technique and achieving similar results. After this series of six subjects, Bier was to receive a spinal anesthetic administered by his assistant, August Hildebrandt. Unfortunately, although Hildebrandt placed the spinal needle correctly, with cerebrospinal fluid flowing freely from it, the syringe was only then discovered to not fit into the hub of the needle. During the efforts to fit the syringe into the hub of the needle, a great deal of cerebrospinal fluid escaped, most of the cocaine to be injected was lost, and the spinal anesthetic was consequently a complete failure. Later that same evening, Bier performed a cocaine spinal anesthetic on Hildebrandt. After the injection, Hildebrandt was temporarily unable to move or feel any sensation in his legs. The profound anesthesia of his legs was demonstrated using increasingly painful stimuli, including a needle inserted down to the femur, a blow with an iron hammer to the shins, forceful avulsion of pubic hair, and "strong pressure and traction" to the testicles. Later that evening, they celebrated their success with wine and cigars. Like all of Bier's previous experimental subjects, Bier and Hildebrandt both experienced severe post-spinal headaches. Hildebrandt's symptoms lasted about four days, while Bier remained confined to bed for nine days.
Intravenous regional anesthesia
In 1908, Bier pioneered the use of intravenous regional anesthesia, a technique which is commonly referred to as a "Bier block". This technique is frequently used for operations of brief duration upon the hand, wrist, and forearm. It can also be used for operations of brief duration upon the foot, ankle, and leg.
In 1903 he joined the faculty of the University of Bonn as a full professor, where he taught until 1907. Then he went to Berlin, where he was appointed Geheimrat Professor of Surgery and Chief Surgeon at the Charité – Universitätsmedizin. Bier was elected President of the German Surgical Society in 1911. Bier treated many important people, such as Kaiser Wilhelm II, family members of Nicholas II of Russia, and Vladimir Lenin. Although he was arguably the most accomplished surgeon of his time, not all of his operations were successful. Hugo Stinnes died on 10 April 1924, about a month after Bier performed a cholecystectomy on him. On 24 February 1925, Bier performed an appendectomy on Friedrich Ebert, the first President of Germany, who had signed the Weimar Constitution into law in 1919. Ebert, who had suffered from appendicitis for two weeks before it was diagnosed, died of septic shock four days after the operation. Upon Ebert's death, Paul von Hindenburg was elected as successor. Bier was Chief Surgeon at the Charité in Berlin until 1928, when Ferdinand Sauerbruch assumed the position. Bier remained at the Charité as Professor Emeritus until his retirement in 1932.
Sports medicine
Bier is also considered to be a pioneer in the field of sports medicine, having played a pivotal role in establishing it as a discipline. Along with Arthur Mallwitz, Bier organized the first lectures in sports medicine at the University of Berlin in 1919. Bier served as director of the Deutsche Hochschule für Leibesübungen in Berlin from its founding in 1920 until 1932. Sauerbruch temporarily headed the Academy until 1933, when Karl Gebhardt assumed the directorship. Gebhardt became the first professor of sports medicine in Berlin. Gebhardt expanded on Bier's methods, adopting an academic approach to sports medicine and awarding degrees.
