In 1911 Abd al-Hadi, along with Rafiq al-Tamimi were founding members of the Paris-based underground al-Fatat nationalist society, which was devoted to Arab independence and unity. He was among the organizers of the Arab Congress of 1913 in Paris. When Faisal I of Iraq arrived in Paris en route to London in December 1918 Ahmad Qadri located Abd al-Hadi introduced him to Faisal who appointed him as the head of the administrative office for the Arab delegation to the Paris Peace Conference, 1919. Abd al-Hadi was later an adviser to Amir Abdullah in Transjordan. On his return to Palestine in 1924, Abd al-Hadi became one of the chief spokesmen of the Palestinian Arab nationalist movement and was elected representative to the 5th and 6th Congress of the Arab Executive Committee for Jenin and to the 7th for Beisan. He was secretary of the Executive Committee's Congress in 1928. In 1930 Abd al-Hadi was a member of the Palestinian Arab delegation to the United Kingdom and a lawyer for the Supreme Muslim Council. In August, 1932 he was a founder, general secretary and first elected president of the Palestinian Istiqlal Party, the first regularly constituted Palestinian Arab political party. He was also the party's representative on the Arab Higher Committee, formed in April 1936, for which he served as general secretary. Abd al-Hadi was a moderate who was prepared to negotiate with members of the Yishuv. He testified to the Peel Commission, "There is no such country .... Palestine is a term the Zionists invented.... Our country was for centuries part of Syria." Abd al-Hadi held some responsibility for the Arab revolt of 1936–39. The Istiqlal Party was banned and he, who was out of the territory at the time, was banned from re-entry to Palestine. The British administration also deported three committee members and two other political leaders in 1937. He was a member of the Palestinian delegation to the London Conference in February 1939. After the 1948 Arab-Israeli war, Awni Abd al-Hadi ended up in Cairo, Egypt with his wife, Tarab Abdul Hadi. In 1948, Abd al-Hadi was a member and appointed Minister for Social Affairs of the Egyptian-sponsored All-Palestine Government headed by Amin al-Husayni. From 1951 to 1955, he was Jordan's minister and later ambassador to Cairo. From 1955 to 1958, he was a Jordanian senator and from 1958 chairman of the Arab League's Legal committee in Cairo. Abd al-Hadi died on 15 March 1970 in Cairo.